Page 6 - Bio Rex NONI Book

PHYSIOLOGICAL REGULATOR OF BASIC METABOLISM

BIO REX® NONI is a physiological regulator of basic metabolism, and in particular lowers blood cholesterol,
inhibits blood lipid oxidation, is a potent free radical neutralizer and inhibitor of cell oxidative damage. By
suppressing chronic levels of inflammation in the peripheral blood vessel walls, by accelerating the blood
vessel endothelium regeneration, by suppressing inflammation, and by normalizing lipid metabolism. Regular
consumption of BIO REX® NONI is recommended as a powerful tool to inhibit the onset or slow the progression
of atherosclerosis. Clinical studies have shown that the controlled NONI fruit administration normalizes excess
cholesterol, in particular HDL “bad” cholesterol, triglycerides, blood inflammatory proteins and myocardial
infarction risk factors in heavy smokers with severe hyperlipidemia. These effects, shown after only one month
of regular consumption, are attributed to the unique NONI iridoid active fraction.

Particularly relevant to these clinical effects are the biochemical capability of NONI (glycosides/ flavonol-
glycosides iridoids, lignan components) to inhibit blood LDL-oxidation toxicity, a key atherogenic factor, which
has been attributed to both a direct free radical scavenging activity of the preparation, and to its marked
lipoxygenase and cyclooxygenase activities. NONI also exerts a direct protective effect on endothelial cells from
the cytotoxic hydroperoxides produced by extensive LDL oxidation. Notably, damnacanthal, a trace
anthraquinone component of NONI fruit, has been shown to contribute to BIO REX® NONI remarkable anti-
inflammatory action through the suppression of nuclear factor-kB (NF-kB) activity response, with resulting
inhibition of the expression of pro-inflammatory cytokines, cyclooxygenase-2, and inducible nitric oxide
synthase.

Type 2 diabetes is associated with increased glucose production due to the inability of insulin to suppress hepatic
gluconeogenesis and promote glycolysis. Insulin inhibits gluconeogenesis by modulating transcription factors
such as forkhead box O (FoxO1). A specific research published in the British Journal of Nutrition concluded that
supplementation with Fermented NONI (fNJ) inhibited weight gain and improved glucose and insulin tolerance
and fasting glucose in animal study model. The research data suggest that Fermented NONI improves glucose
metabolism via FoxO1 regulation in diabetic patients.