Page 7 - Bio Rex NONI Book

BIO REX® NONI is also clinically effective in the prevention and treatment of myocardial, cerebral, renal, and
retinal ischemia. By enabling restoration of a physiological blood supply (through different documented
mechanisms), by reducing blood vessel tone and peripheral resistance (through both a spasmolytic and direct
vasodilator action on both endothelium and muscle), by reversing the "ischemia-reperfusion" pattern leading to
vascular constriction, and thus protecting affected tissues from the relative strong oxidative damage, by an
effective inhibition of glucose intolerance under ischemic stress through insulin stimulation and, finally, by
decreasing neuronal damage scores in an experimental model of cerebral focal ischemia, BIO REX® NONI
provides effective prevention and management of cardiac insufficiency, angina pectoris, infarction and stroke
of vital organs, and protection against ischemia-induced central and peripheral complications.

BIO REX® NONI is clinically effective in the control of hypertension, by directly lowering arterial blood pressure,
decreasing peripheral vessels resistance, increasing capillary blood flow. Its diuretic properties enhance its
hypotensive effects. In addition, BIO REX® NONI is clinically effective in the prevention and management of
diabetes mellitus induced heart problems. By suppressing the protein-glycation reaction and consequent vital
tissue damage, by accelerating wound-healing process, by lowering blood cholesterol and glucose levels, and by
inhibiting lipid oxidative damage in blood flow and target vascular tissues, if assumed on a regular basis, BIO
REX® NONI stands as an elective preventive and co-treatment support for life impairing and quality of life-
reducing diabetic complications. In addition, the documented xantineoxidase inhibitory activity of NONI fruit
juice has proven effective in the amelioration of gout and gout-like disease diabetic complications.

The pain killing (anti-nociceptive) effect, demonstrated in controlled clinical studies on cancer patients, along
with marked anxiolytic and sedative effects, are supportive of the amelioration of the quality of life in these
chronic patients, also enabling the facilitation of cognitive processes, and memory improvement.