Page 1062 - The Toxicology of Fishes

1042 The Toxicology of Fishes

copper, 442 endogenous, 694–696
dioxin-like chemical, 351 estradiol, 163, 362
DMBA, 540, 541 estrogen, 164
DNA, 441 ethane, 441
endogenous, 190 ethylene, 441
ethanol, 296 fecal elimination of, 86
first-pass, 174, 204, 329 formation of, 100, 105
intestinal, of PCB 77, 72 genotoxic, 179
hepatic, 118, 121 glutathione, 540
hormone, 83 hydrophilic, 330
4-hydroxy-2-nonenal (HNE), 301 hydroxy steroid, 186
inhibition of, 126 hydroxylamine, 352
intestinal, 72, 329 kinetics of, 118
lipid, 475 lipophilic compound, 62, 86, 154
liver, 349–352 mercapturic acid, 206
liver toxicity, and, 368–369 naphthalene, 91
oxidative, 277 β-naphthoflavone, 198
pentachlorophenol, 85 organophosphate, 213
phase II, 208 PAH, 43, 163, 200, 366
phospholipid, 440 in bile, 885–886, 890
protein, 441, 475 PCB, 189, 190, 200, 205, 468
rate, 63, 115, 118 petroleum hydrocarbon, 352
tricaine methane sulfonate (MS 222), 78 phenol, 122, 183, 200, 208
triglyceride, 358 procymidine, 470
xenobiotic, 368, 368–369 pyrethroid, 810
metabolites, 18, 43, 62, 83, 96, 97, 100, 122, 158, quinone, 607
185, 190, 197, 200, 206, 207, 235, 298, 329, reactive diol epoxide, 180
352, 359, 368, 369, 688, 712, 884 stereoisomer, 207
AAF, 369 sulfonium ion, 196
acetamidofluorene, 203 TCDD, 41
acetaminophen, 370 testosterone, 172
2-acetylaminofluorene, 542 tricaine methane sulfonate, 78
aflatoxin, 572 vinclozolin, 470
aflatoxin B (AFB ), 211, 212, 540 xenobiotic, 330, 352, 362, 364
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aldicarb, 178 metabolomics, 253, 259
aromatic amino acid, 206 metal chelates, 298
aromatic hydrocarbon, 188, 374 metal species, 287, 440
aryl amine, 200 metalloenzymes, 286
ascorbate, 283 metalloids, 11, 115
BaP, 43, 44, 158, 163, 182, 194, 207, 208, metallothioneins, 258, 276, 286, 288, 302, 305,
209, 351, 511, 575 403, 499, 606, 610, 611, 627, 689–690, 712
benzoic acid, 205 acclimation, and, 799
biliary, 86, 352, 362 metal-responsive elements (MREs), 258
bilirubin, 362 metal-responsive transcription factor (MTF-1), 258
carbon tetrachloride, and, 370 metals, 11, 16–17, 85, 129, 300, 328, 374, 406,
carcinogenic, 163, 190, 191, 194, 203, 369, 440–443, 497, 499–504, 603, 627, 646, 689,
542 745, 824; see also specific types
concentration of, 122 bioavailable, 791
CYP2E1, 296 carrier proteins, and, 63
DDT, 91, 329 cationic, 12, 13, 20, 28–35
dermal excretion of, 90 detoxification of, 286
dihydropyridium, 426 dietary uptake of, 17, 18
DMBA, 163, 540 dissolved, 12