Page 1059 - The Toxicology of Fishes

Index 1039

in English sole, 894–895 nonylphenol, and, 990
in medaka, 196 nuclear receptors, 352–359
carcinogenesis, 890 oxidative stress in, 296
polycyclic aromatic hydrocarbons and, parenchyma, 335, 349, 350
564 peptide, 188
CDNB conjugation in, 196 pollutants, and, 374–376
cells, 335–342 portal blood flow, 120
copper in, 286 putative stems cells, 339–340
CYP1A activity in, 351, 696 reactive oxygen species in, 889
CYP1A1 in, 888 regeneration, 565
CYP2N in, 167 structure, 331–342
CYP2N2 in, 168 sulfate conjugates in, 200
CYP2P in, 168 sulfotransferase in, 201, 203
CYPs in, 155 theta-like glutathione S-transferase in, 196
cytosol, 160, 179, 203 toxicity, 327–378
cytosolic glutathione S-transferase, 199 metabolism, and, 368–369
detoxification enzymes, 944, 947 tubules, 332, 335, 343, 410
development, 343–348 tumorigenesis, 565
DNA adducts in, 891, 893, 903 tumors, 377, 533, 534, 537, 540, 541, 543,
epithelial cells, 338 556, 557, 558, 560, 562, 563, 564, 565,
epoxide hydrolase activity, and, 181 566, 567, 568, 569, 570, 571, 572, 574,
epoxide hydrolysis in, 181 576, 619, 620, 710
estrogen in, 472 UGTs in, 188, 189
fish vs. mammal, 331, 332, 349, 360 weight, 566, 570
flavin-containing monooxygenase activity in, sex, and, 565
177 xenobiotic elimination, and, 83–86
function, 330–331, 348–352 liver X receptor (LXR), 358, 363
glutathione S-transferase in, 191, 192, 194, LMC1, 164
195, 619 LMC2, 166–167
GST-A in, 193 LMC5, 169
GST–CDNB activity in, 198 locomotion, 433
high-affinity binding in, 120 directed/undirected, 428
hypertrophy, 82 lotic systems, 737
injury, xenobiotic-induced, 367–368 lowest-observable-effect levels (LOELs), 746,
lesions, 352, 375, 377, 574, 575, 693, 699, 758
888, 889, 894–895, 902, 903, 906, 908, lowest-observed-effect concentration (LOEC),
911 664, 675, 677, 758, 762
in English sole, 888, 894–895, 902, 903, LT , 669, 799
50
906, 911 lubricants, 198
in Lake Michigan lake trout, 847 lucifer yellow, 85
LMC1 in, 164, 167 luciferase, 429
LMC2 in, 166 Lumbriculus variegatus, 40
lobules, 331, 332, 333, 335, 339 lung, paraquat, and, 297
metabolic zonation in, 350 lungfishes, 283
metabolism, 121, 349–352 luteinizing hormone (LH), 458–462, 468, 472
metallothionein, and, 690 luteinizing-hormone-releasing hormone (LHRH),
microsomes, 182, 208 468
neoplasms, 374, 375, 533, 537, 564, 565, Lutjanus apodus, 444
572, 574, 575, 577, 710 Lutjanus mahogoni, 444
brown bullhead, 710 lymphocytes, 490, 491, 492, 496, 498, 503, 504
mummichog, 577 lymphoid involution, 507, 508
rainbow trout, 533, 534, 535, 540 lymphoid organs, 490–492
white sucker, 710 lymphoid tissues, 492–493