Page 1058 - The Toxicology of Fishes

1038 The Toxicology of Fishes

lectins, 494 lipid metabolism, 475, 822
Leiostomus xanthurus, 329 lipid mobilization, 81–82
lemon shark (Negaprion brevirostris), 179 lipid oxidation, 191, 342
lemon sole (Microstomus kitt), cytochrome P450 lipid partitioning, 128, 884
induction in, 351 lipid peroxidation, 194, 276, 280, 285, 292–293,
lentic systems, 734, 737, 741, 743 296, 298, 300, 301, 305, 307, 371, 372, 468,
Lepomis cyanellus, 609 544, 563, 690, 694, 703, 706, 797, 798, 889
Lepomis macrochirus, 43, 167, 213, 430, 437, initiation, 292
445, 609, 743; see also bluegill sunfish propagation, 292
Leptacottus armatus, 213, 910 lipid peroxide, 292
Letocheirus plumulosus, 38 lipid peroxyl radicals, 285, 292
leucine-enkephalin, 421 lipid solubility, 82
leukocytes, 490, 497 lipid–water partition coefficient, 61, 119
leukotrienes, 154, 190 lipids, 19, 80, 85, 115, 117, 119, 127, 128, 129,
Leydig cells, 76, 459, 460, 461 132, 235, 341, 349, 351, 425, 883
life-cycle exposures, 950–951 bioactive, 368
life stages of fish, 572 dietary, 16, 18, 74
ligand-activated transcription factors, 249, 258 homeostasis of, 357, 358
ligand binding, 240–249, 253, 258, 353, 461, 464, membrane, 194, 275
465 micelles of, 18
affinities, 354, 472 normalization of, 19, 20
assays, 241, 247–249 nuclear receptors, and, 358
curves, 241, 243 somatic, 91
domain, 353, 354, 357, 463 storage of in liver, 374
nonspecific, 243, 247 toxicity, and, 609
ligand–protein interactions, 79 lipofuscin, 342, 372, 375, 930
ligand–receptor interactions, 239–253, 350 lipogenesis, 358
ligands lipoic acid, 285
abiotic, 12 lipophilic compounds, 62, 66, 67, 72, 74, 80, 81,
AhR, 256 82, 83, 86, 88, 91, 154, 440, 506, 507, 810,
binding of, see ligand binding 989, 991
biotic, 12 metabolism of, 330
model for, 32 lipophilicity, 429, 436, 806, 810
bound vs. free, 247 lipopigments, 372, 373, 375, 376, 377–378
copper, and, 29 lipopolysaccharide (LPS), 368
endogenous, 353 lipoproteins, 74, 292, 357, 358
exogenous, 353 lipovitellin, 460
inorganic, 29, 30, 36 lipoxygenases, 179
organic, 29, 30 lithocholate, 185
photoaffinity of, 247 lithocholic acid (LCA), 360, 365
tritium-labeled, 247 littoral enclosures, 737, 740, 742
Limanda limanda, 178, 373, 558, 574; see also littoral mesocosms, 951
dab, flatfish live-bearing teleosts, 91
limnocorrals, 737, 740, 742, 743 liver, 18, 63, 74, 75, 78, 85, 88, 92, 92–95, 103,
lindane, 119, 190, 373, 437, 438, 506–507, 623, 110, 115, 117–118, 163, 172, 174, 205, 206,
662, 742 207, 211, 252, 406, 505, 511, 535, 574, 575,
isomers of, 506–507 606, 706, 711, 797, 810, 886
linear alkylbenzene sulfonate, 78 alcohol dehydrogenase, 178
linear aromatic hydrocarbons (LAHs), 881, 885, aryl hydrocarbon receptor, and, 160
910 as target organ, 328–329
linuron, 375 BaP, and, 541
lipases, 74, 180 cancer, 196, 208, 307, 535, 542, 894–895
lipid membranes, 16, 60 in brown bullhead, 307, 535