Page 1056 - The Toxicology of Fishes

1036 The Toxicology of Fishes

Japanese flounder (Paralichthys olivaceus) P-glycoprotein, and, 362, 365
interleukins, 494 PHAH resistance in, 366
tin, and, 504 polycyclic aromatic hydrocarbons, and, 541
Japanese medaka (Oryzias latipes), see medaka pulp mill effluent, and, 954
jaundice, 307 TCDD resistance in, 833
juglone, 282, 296 TCDD sensitivity, 843
kinetic modeling, 127–128, 131
K K , see Michaelis–Menten constant
m
+
K , 403, 405, 409 K , see organic carbon–water partition coefficient
oc
K , see acid dissociation coefficient Koch’s postulates, 859
a
K , see dissociation constant, equilibrium K , see octanol–water partition coefficient
ow
D
K , 245, see also efficacy kraft mills, 935, 954
E
Keap1, 289, 290 K-ras, 889–890
kepone, 469, 472, 473 Kruskal–Wallis test, 746
-tolerant mummichog, 609 Kupffer cells, 331, 342, 368
ketoconazole, 163, 173, 174 Kyphosous sectatrix, 166
–2
α-ketoglutarate (αKG ), 88–89
ketones, 294 L
ketosteroid isomerase, 193 lactate, 406
ketosteroids, 193 lactate dehydrogenase, 691, 702
11-ketotestosterone, 460, 848, 897, 982 Lagodan rhomboides, 166
kidney, 58, 63, 78, 85, 86–90, 92, 95, 103, 106, Lahn River, 695
110, 114, 117–118, 163, 166, 172, 205, 206, Lake Erie, 43, 821, 855
211, 342, 368, 401, 402, 406, 490, 491–492, lake trout, mercury concentrations in, 826
501, 503, 506, 511, 606, 692, 702, 711, 797, sea lamprey in, 823
810, 829 walleye in, 824, 825
ACTH, and, 410 lake herring, TCDD sensitivity, 843
anion transporter proteins in, 205 Lake Huron, 824, 825
arterial blood flow to, 120 commercial fishing in, 856
cadmium concentrations in, 409 HAHs in, 857
copper, and, 409–410, 502 lake trout in, 861
CYP1A1 in, 888 reproduction of, 820, 824
CYP3A expression in, 174 mercury concentrations in, 826
ECSOD, and, 279 PCBs in, 857
epoxide hydrolase activity, and, 181 salmonines, thiamine deficiencies in, 850
osmoregulation, and, 409–410 sea lamprey in, 823
reactive oxygen species in, 889 Lake Michigan, 82, 820, 822, 824, 825, 850
tumors, 564, 572 alewife population in, 849
UGT1B1 mRNA levels in, 189 Chinook salmon fry in, 859
UGTs in, 188 Chinook salmon in, 848
killifish (Fundulus heteroclitus), 160, 163, 167, Coho salmon in, 850
168, 169, 172, 174, 237, 674; see also commercial fishing in, 856
mummichog HAHs in, 857
AhRs in, 827 lake trout in, 859, 861
ARNT proteins in, 827 HAHs and, 846, 847, 859
creosote-resistant, 366 mercury concentrations in, 826
CYP1A, 162 organic extract made from, 837
CYP2N in, 167 PCDD/PCDF concentrations in, 826
dioxin-like compounds, and, 604 PCBs in, 857
hepatic tumors in, 366 sea lamprey in, 823
ketoconazole exposure, 175 Lake of the Arbuckles, 548
least (Heterandria formosa), cadmium- Lake Ontario, 657, 820, 824, 825, 826
resistant, 611, 622 commercial fishing in, 856