Page 1052 - The Toxicology of Fishes

1032 The Toxicology of Fishes

hagfish (Myxine sp.), 162, 422 hepatic extraction ratio, 92
haloacetic acids, 119 hepatic lesions, 352, 375, 377, 574, 575, 693, 699,
halogen, absorbable organic, 954, 957 889, 894–895, 902, 903, 906, 911
halogenated alkenes, 196 hepatic necrosis, 929, 930
halogenated aromatic hydrocarbons (HAHs), 160, hepatobiliary transport, 359, 361, 362, 365
350, 507–510, 821, 822, 824, 825, 826, 839, hepatocarcinogenesis, 207, 209, 210, 566
840, 845, 846, 847, 850, 851, 852, 853, 854, aflatoxin-induced, 564
855, 856, 857, 858, 859, 860, 861, 881, 885, hepatocarcinogenicity, 369, 371, 375
888, 910 hepatocarcinogens, 534, 539, 542
halogenated hydrocarbons, 160, 329, 497 hepatocellular carcinoma (HCC), 209, 537, 618,
halogenated organic chemicals, 128 619, 710
handling, of fish, 411, 690, 691, 700 hepatocytes, 83, 84, 121, 122, 189, 197, 330, 331,
Ha-ras, 890 332, 333, 335–336, 337, 338, 339, 343, 349,
hardness, water, 24, 30, 31, 60, 809, 813 350, 351, 353, 359, 360, 361, 362, 365, 368,
harmonization, 767 370, 371, 375, 378, 560, 566, 620, 797, 798
hazard definition, 902 binucleated, 374
hazard identification, 760–762, 766 dioxin-like compound sensitivity of, 614
hazard quotient (HQ), 764, 771, 787 fish vs. mammal, 333
head kidney, 166, 167, 490, 494, 495, 503, 507, in vitro preparations of, 352
511 necrotic, 371
PAHs, and, 899 Oatps, and, 85
tributyltin, and, 503 rare, 607
heart, 166, 167, 168, 356, 423, 692, 711, 829, 834 skate, 85
altered gene expression in, 252 sulfonation, and, 201
heat shock protein 90 (Hsp90), 160, 253 toxic exposure, and, 372–374
heat shock proteins, 160, 253, 286, 295, 463, 464, ultraviolet-exposed, 553
690, 690–691, 696, 712 hepatopancreas, 206, 331
heavy metals, 80, 120, 202, 258, 372, 403, hepatosomatic index (HSI), 565, 566, 706, 976
407–408, 409, 410, 469, 475, 477, 499, 558, hepatotoxicity, 330, 360, 368, 369, 370, 371, 378,
662, 881 822
calcium, and, 405 cocaine, 296
helix–loop–helix, 160, 826, 828 ethanol, 296
hematin, 199 methylmercury, 300
hematological indices, 701 heptachlor, 806, 812
hematology, 700–703, 713 heptachlor epoxide, 91
hematopoiesis, 490, 508 2,2′,3,4,4′,5,5′-heptachlorobiphenyl, 129
mercury, and, 502 herbicides, 206, 257, 297, 549, 978, 983
TCDD, and, 830, 831 carbamate, 431
heme, 154, 185, 191, 277, 279, 330, 354 organophosphorus, 431
catabolism, 695 predator–prey interactions, and, 428
degradation products, 199 herbivorous fish, 38
iron, 157 hermaphroditism, 971, 990
heme oxygenase, 283, 288, 308, 691 herring (Clupea harengus), 80, 162
Hemilepidotus hemilepidotus, 75 Heterandria formosa, 611, 622
hemocyanins, 279 heteroatom dealkylations, 157
hemoglobin, 80, 277, 428, 701, 707 heteroatom oxygenation, 157
degradation, 342 heterocyclic compounds, 497, 618
hemosiderin, 342 heterophagy, 372
Henderson–Hasselbach equation, 61 Heteropneustes fossilis, 368
heparin sulfate, 279 hexachlorocyclohexane, 506, 711
hepatic clearance, 92–95, 330 hexachlorohexane, 438
hepatic CYP2B immunoreactive proteins, 164 hexachlorophene, 427
hepatic elimination, 117–118 hexameric response elements (HREs), 353