Page 1054 - The Toxicology of Fishes

1034 The Toxicology of Fishes

hydroxyl ions, 36 hypothyroidism, 846, 847
hydroxyl radicals, 158, 275, 544 hypoxia, 79, 295, 370, 430, 441, 445, 707, 835,
hydroxylamine, 352 842
hydroxylapatite (HAP), 247, 248 hypoxia-inducible factor (HIF), 827
7α-hydroxylase, 360 hypoxia-inducible factor-1α (HIF-1α), 251, 827,
11β-hydroxylase (P450c11), 460 828
17α-hydroxylase (P450c17), 460
21-hydroxylase (P450c21), 460 I
hydroxylated polychlorinated biphenyls, 471 IC , 950
25
hydroxylation, 157, 167, 212, 360, 460, 540, 542, Ictalurus melas, 198, 213, 349, 500
810 Ictalurus natalis, 609
AFB , 211 Ictalurus nebulosus, 342, 534, 535, 548; see also
1
cholesterol, 360 brown bullhead
testosterone, 172, 351 Ictalurus punctatus, 16, 66, 163, 176, 179, 213,
6β-hydroxylation, 351 304, 329, 338, 373, 490, 493, 494, 496, 497,
N-hydroxylation, 207 499, 505, 509, 510, 553, 560, 567; see also
7-hydroxymethyl-12-methylbenz(a,h)anthracene, channel catfish
204 imidazoles, 163
6-hydroxymethylbenzo(a)pyrene, 204 immune cells, 490
N-hydroxy-N-acetamidofluorene, 204 immune system, 489–513, 622
N-hydroxy-N-acetylaminofluorene, 203, 204 adaptive, 496–497
4-hydroxynonenal, 194, 280, 544 immunity, 500, 501, 503, 507, 511
hydroxynonenals, 191, 192, 194 cell-mediated, 497, 500, 501, 504
17α-hydroxyprogesterone, 460 humoral, 496–497, 499, 501, 504, 505
2-hydroxypyrimidine, 179 T-lymphocyte-dependent, 503
3β-hydroxysteroid dehydrogenase (3β-HSD), 460 immunoglobulin, 496, 497, 499, 503, 506
11β-hydroxysteroid dehydrogenase (11β-HSD), immunohistochemistry, 160, 712
460 immunology, 489–497, 897–899
6β-hydroxytestosterone, 172 immunomodulation, chemical, 497–512
5-hydroxytryptamine, 421, 423 immunosuppression, 499, 501, 505, 507, 508,
5-hydroxytryptophan, 468 511, 512
Hylebos Waterway, 881, 893, 895, 897, 899, 901, immunotoxicants, 497, 498, 503, 702
909, 910, 911 immunotoxicity, 822
hyperactivity, 439, 462, 808, 814 quinone, 297
hyperexcitability, 436, 437, 438, 441 TCDD, 508
hyperglycemia, 475 immunotoxicology, 497, 498, 499
hypermethylation, 599 in vivo assays, 249–251
hyperplasia, 410, 904 incipient lethal level (ILL), 799
hypertrophy, 410 inclusion bodies, 375
intestinal, 82 indole-3-carbinol (I3C), 160, 213, 563–564, 566,
liver, 82 571
hypoactivity, 434, 439, 814 indole-3-carbonyl, 369
hypocalcemia, 407 indolo-(3,2-b)-carbazole, 160
hypocellularity, 507, 508 indomethacin, 208
hypochlorous acid (HOCl), 278 inducible nitric oxide synthases, 276
hypodermis, 75, 76 inflammation, 286, 295, 342, 490, 495
hypothalamic–pituitary–gonadal axis, 458–462, chronic, 278
466–467, 848, 948, 976 infusion dose, of toxicant, 99
hypothalamic–pituitary–interrenal axis, 410, inhalation, 76, 106
474–476 models, 114
hypothalamic–pituitary–thyroid axis, 476–477 nitromethane, 572
hypothalamus, 410, 421, 458, 462, 465, 467, 474, xenobiotic, 57
475 inhibin, 459, 460