Page 1243 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

1174 Index

VetBooks.ir Drug (Continued) Edema, 221, 991 Embellesia oxytropis (E. oxytropis).
EDI. See Estimated daily intake (EDI)
sensitization, 106 107
See Undifilum oxytropis (U. oxytropis)
“street drugs”, 613
Embryonic and fetal development
EDTA. See Ethylene diaminetetraacetic acid
(EDTA)
withdrawal/withholding periods, 127
germ cell layers, 292 293
Drug Enforcement Administration (DEA), 386, EEA. See European Economic Area (EEA) blastocyst formation and differentiation of
387t Effexor. See Venlafaxine sex determination and sexual differentiation
Drug-induced liver injury (DILI), 239 EFSA. See European Food Safety Authority of reproductive function, 293 295
Drugs of abuse, toxicity of (EFSA) Embryonic stem cells (ESCs), 153
barbiturates, 390 392 EG. See Ethylene glycol (EG) Embryos, pathological effects of petroleum in,
hallucinogens and dissociative drugs, Egg(s) 666
401 406 discoloration, 975 976 Emetics, 361, 377, 395, 481, 597, 1145 1146
illicit drugs residues in, 988 989 EMG. See Electromyography (EMG)
and large animals, 386 EGS. See Equine grass sickness (EGS) Emission of secretions of accessory sex glands,
and small animals, 385 386 Egyptian fruit bats (Rousettus aegyptiacus), 286
marijuana, 387 390 436 Emollient laxatives, 907
opioids, 392 394 Egyptian spiny mouse (Acomys cahirinus), 590 Emphysema, 222 223
other CNS depressants, 394 395 EI. See Electron ionization (EI) Empirical (compartmental) toxicokinetic
stimulants, 395 401 Ejaculation, 286 models, 135 137. See also
veterinarian and drug enforcement Elapids, 796 Physiologically based toxicokinetic
administration, 386 mechanism of action, 796 models (PBTK models)
Dry matter (DM), 425 toxicity, 796 CL, 136
Dry-ice phenomenon, 206 207 treatment, 796 first-order decline in plasma concentrations,
dSPE. See Dispersive solid-phase extraction Electrocardiogram (ECG), 227, 635, 1142 135f
(dSPE) Electrocardiography. See Electrocardiogram flip-flop kinetics, 136, 136f
DT-diaphorase, 588 (ECG) half-life, 136
DTPA. See Diethylenetriamine pentaacetic acid Electromyography (EMG), 505, 1038 measures of absorption, 136
(DTPA) Electron capture detector. See Electron capture residues, 136 137
DU. See Depleted uranium (DU) dissociation (ECD) two-compartment open models, 135f
Dumbcane (Dieffenbachia spp.), 54, 63 64 Electron capture dissociation (ECD), 166, 1125 volume of distribution, 136
DUMBELS. See Diarrhea, urination, miosis, Electron ionization (EI), 1128 Emulsified concentrate (EC), 525
bronchospasm, emesis, lacrimation, and Electron microscopy, 322 Emulsifiers, 117
salivation (DUMBELS) Electron transport chain (ETC), 447 Endocannabinoids, 389
Dursban. See Chlorpyrifos Electronic Submissions Gateway (ESG), 97 Endocrine disrupting chemicals (EDCs), 273,
Dye uptake assays, 154 Electronic Submissions System (ESS), 97 278
Dyspnea, 73 Electrophiles, 245 effects, 296 298
Dysregulation of energy balance, 1046 Electrophysiological dysfunction, 227 epigenetic mechanisms of action, 279 280
Electrospray ionization (ESI), 1128 1129, Endocrine disruption, 273, 275 280, 296 297,
1129f 738
E Electrospray ionization/tandem MS instruments androgenic and estrogenic effects of
Eagle owl (Bubo bubo), 593 (ESI/MS/MS), 165 166 xenobiotics, 278
Ear mites (Otodectis cynotis), 539 541 ELEM. See Equine leukoencephalomalacia aryl hydrocarbon receptor-mediated,
Eastern coral snake (M. fulvius fulvius), 796 (ELEM) 278 279
Eastern screech-owls (Megascops asio), 592 Element, 327 in domestic animals, 298
“Eat and pull” management strategy, 843 Elemental analysis, 1119 1121 endocrine disrupting chemicals, 278
EBDCs. See Ethylenebisdithiocarbamates AA, 1120 endocrine disruptors, 278
(EBDCs) ICP-MS, 1120 1121 fungicides, 578
EC. See Emulsified concentrate (EC); ICP-OES, 1120, 1121f herbicides, 563 564
European Commission (EC) sample preparation, 1121 hormonally active agents, 278
ECD. See Electron capture dissociation (ECD) Elemental sulfur, 483, 573 574 in humans, 297 298
ECF. See Extracellular fluid (ECF) Elevated blood COHb, 635 hypothesis, 813
ECG. See Electrocardiogram (ECG) Elevated liver enzymes, 399 independent of receptor-mediated
eCG. See equine chorionic gonadotropins ELF. See Epithelial lining fluid (ELF) interactions, 277
(eCG) Elimination, 133 134, 136 138, 907 mechanisms, 277
Ecgonine methyl ester, 396 of botulinum toxins, 746 of “non-reproductive” endocrine systems,
ECHA. See European Chemicals Agency molybdenum, 464 280
(ECHA) renal selenium, 472 in wildlife species, 297
Ecstasy, 198, 385, 395 selenium, 471 472 Endocrine disruptors, 278, 805, 813 814
ECVAM. See European Centre for Validation ELISA. See Enzyme Linked Immunosorbent Endocrine regulation of spermatogenesis,
of Alternative Methods (ECVAM) Assay (ELISA) 285 286
EDBCs, 576 “Elixir Sulfanilamide” tragedy, 89 Endocrinology
EDCs. See Endocrine disrupting chemicals Ellman method, 1122 of pregnancy, 291 292
(EDCs) EMA. See European Medicines Agency (EMA) of puberty, 281
EDDI. See Ethylenediamine dihydroiodide Emaciated California quail (Callopepla Endogenous steroid hormones, 110
(EDDI) californica), 593 Endometrial epithelial cells, 828