Page 1252 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Index 1183

VetBooks.ir LD 50/30 values for domestic mammals, 331t ISD. See Iron storage disease (ISD) Kalmia spp., 230
Isocitrate dehydrogenase (ICD), 990 991
long-term impacts of radiation exposure in
Kaolin, 381
Kaopectate, 1146
animals, 332 333
Isocupressic acid (ICA), 861t, 863
measurement, 327 328
mitigating acute radiation exposures in Isoflavones, 817, 818t, 826 Karenia brevis (K. brevis), 206 207, 712
Kefauver-Harris Amendment, 89
Isoflavonoids, 817 819
animals Isoflurane anesthesia, 375 Kelocyanor. See Dicobalt-EDTA
decontamination, 334 Isomers, gossypol, 969 Kepone, 510, 510f
minimizing exposure, 333 Isoprocarb, 496, 502t Keratin, 223
prophylaxis, 333 Isopropanol, 647 Keratinized tissues, 411
treatments and monitoring, 334 335 poisoning, 647 Keratopathy, 75
triage and screening, 334 toxicosis, 649 650 Kerner’s disease. See Food-borne botulism
sources of radiation, 328 329 diagnosis and treatment, 649 650 “Keshan disease”, 469
medical uses of radiation in human and toxicokinetics, 649 Kestrel (Falco tinnunculus), 593
veterinary medicine, 329 Isopropyl alcohol (IPA). See Isopropanol Ketamine, 205, 385 388, 403 405
natural sources, 328 Isopropyl-methylphosphonic acid (IMPA), 83 clinical symptoms, 404 405
nuclear power, 328 329 Isoproterenol, 392 mechanism of action, 404
nuclear weapons, 328 Isoproturon, 560 toxicity, 403 404
sterilization of food, 329 Isotaxine B (C 33 H 45 NO 8 ), 947 toxicokinetics, 404
X-rays, 327 Isoxazoles, 960 962 treatment, 405
Ionophores, 53, 64 65, 233, 720, 1073 1075 mechanism of action, 961 S-Ketamine, 404
effect on ion and water dynamics, 1078f pharmacokinetics/toxicokinetics, 961 3-Ketocarbofuran, 496 500
mechanism of action, 1077 1078 toxicity, 961 Ketoprofen, 358
pharmacokinetics, 1076 1077 treatment, 961 962 Khat. See Catha edulis (C. edulis)
pharmacology, 1075 1076 Itai-itai disease, 419 420 KI. See Potassium iodide (KI)
toxicity Italy black locust (Robinia pseudoacacia), 54, Kidney
acute oral toxicity, 1081t 903 cadmium, 419
biomarkers, 1086t Ito cells. See Hepatic stellate cells (HSC) toxic effects on
clinical signs, 1082 1083, 1082t, 1083t ITRI. See Inhalation Toxicology Research acute renal failure, 261
diagnosis and differential diagnosis, Institute (ITRI) CRF, 261 262
1086 1088 IV. See Intravenous (IV) distal nephron/renal papillary injury, 266
histopathologic findings, 1084 1085 IV CaEDTA. See Intravenously CaEDTA (IV glomerular injury, 265
laboratory findings, 1085 1086 CaEDTA) patterns of toxic renal injury, 262 266
occurrence, 1079 1082 Ivermectin, 539, 545t proximal tubular injury, 265
pathogenesis, 1079 Ivermectin hepatotoxicity, 168 sites of renal damage, 262f
postmortem findings, 1083 1084 Ixodes brunneus (I. brunneus), 785 urinary tract toxicants, 263t
toxicosis, 1086 1087 Ixodes holocyclus (I. holocyclus), 785 Kill fleas (Ctenocephalides felis), 539 541
treatment, 1088 1089 Ixodes ricinus (I. ricinus), 785 Kinetic parameters, 133, 135
Ioxynil, 563 Ixodes rubicundus (I. rubicundus), 785 Klamath Weed. See St. John’s Wort
IP. See Inositol phosphate (IP) Ixodida, 785 (Hypericum perforatum)
IP injection. See Intraperitoneal injection (IP mechanism of action, 785 Knapweeds (Centaurea spp.), 882 885
injection) toxicity, 785 clinical signs, 884
IPCS. See International Programme on treatment, 785 habitat and distribution, 884
Chemical Safety (IPCS) pathology, 884
Ipomoea violacea (I. violacea), 402 prevention and treatment, 885
Iraqi military, 71 J toxicology, 884
IREC. See Institute for Game and Wildlife Jacob’s Lily. See Convallaria majalis “Knockdown” phenomenon, 516
Research (IREC) (Liliaceae family) Krebs cycle, 619 620
Iron (Fe), 248, 433, 726 727, 1109 1110 Japanese quail (Coturnix japonica), 592 Krokodil. See Desomorphine
iron-deficiency anemias, 433 Japanese yew (Taxus cuspidata), 947 Kumho, 182
mechanism of action, 434 Jasminum officinale. See Jessamine (Jasminum Kumho Tire, 182
pharmacokinetics/toxicokinetics, 433 434 officinale) Kupffer cells, 243, 246
poisoning, 434 435 Jervanines, 877
toxicity, 434 436 Jessamine (Jasminum officinale), 54, 63 64
acute toxicity in dogs, cattle, pigs and Jimsonweed (Datura stramonium), 54, 63 64, L
adult horses, 435 201, 899 Labdane resin acid isocuppressic acid, 863
iron storage disease, 436 Joint Meeting on Pesticide Residues (JMPR), Label-free strategy, 165
neonatal horses, 435 436 573 Laboratory Information Management System
neonatal pigs, 435 Jurisdiction, 177 178 (LIMS), 1119
treatment, 436 JWH-018. See 1-penthyl-3-(1-naphthoyl) indole Laboratory of Toxicology of Ghent University
Iron storage disease (ISD), 436, 726 727 (LTGU), 45
Irradiation of food, 329 Laboratory safety studies, 93
Irritant cathartics, 907 K Lactate, 392
Irritant fatty acids, 379 380 Kainate (KA), 205 Lactate dehydrogenase (LDH), 155, 232, 1085
Irritant laxatives, 379 380 Kalanchoe spp., 230 LDH-1, 227