Page 1363 - Small Animal Internal Medicine, 6th Edition
P. 1363
CHAPTER 81 Selected Neoplasms in Dogs and Cats 1335
VetBooks.ir
A B
FIG 81.9
Left lateral thoracic radiographs in a cat with an injection site sarcoma and metastatic
pulmonary disease before (A) and after doxorubicin/cyclophosphamide chemotherapy
(B). Note marked reduction in the size of the pulmonary nodules.
cyclophosphamide, doxorubicin and cyclophosphamide, or Lana S, et al. Continuous low-dose oral chemotherapy for adjuvant
carboplatin. One of the author’s clinics has seen objective therapy of splenic hemangiosarcoma in dogs. J Vet Intern Med.
complete or partial responses in cats with nonresectable or 2007;21:764.
metastatic ISS treated with doxorubicin/cyclophosphamide Liptak JM, et al. Retroperitoneal sarcomas in dogs: 14 cases
combinations (Fig. 81.9) or with carboplatin alone; some of (1992-2002). J Am Vet Med Assoc. 2004;224:1471.
these cats have been in remission for longer than 1 year. If O’Brien RT. Improved detection of metastatic hepatic hemangio-
sarcoma nodules with contrast ultrasound in three dogs. Vet
metastatic disease is already present, chemotherapy is not Radiol Ultrasound. 2007;48:146.
usually effective. Ogilvie GK, et al. Surgery and doxorubicin in dogs with hemangio-
In cats with nonresectable, high-grade ISS, the authors have sarcoma. J Vet Intern Med. 1996;10:379.
seen objective responses to doxorubicin/cyclophosphamide Pirie CG, et al. Canine conjunctival hemangioma and hemangio-
or doxorubicin/lomustine chemotherapy, and neoadjuvant sarcoma: a retrospective evaluation of 108 cases (1989-2004). Vet
chemotherapy (i.e., chemotherapy to decrease the size of Ophthalmol. 2006;9:215.
the mass, then surgery, then additional chemotherapy) has Sorenmo KU, et al. Chemotherapy of canine hemangiosarcoma
been used successfully in cats with high-grade ISS in the with doxorubicin and cyclophosphamide. J Vet Intern Med.
clinic. Small molecule TKIs are currently being investigated 1993;7:370.
in cats with ISSs; however, initial studies have not shown Sorenmo KU, et al. Efficacy and toxicity of a dose-intensified doxo-
overwhelming response rates. rubicin protocol in canine hemangiosarcoma. J Vet Intern Med.
2004;18:209.
Weisse C, et al. Survival times in dogs with right atrial hemangio-
Suggested Readings sarcoma treated by means of surgical resection with or without
adjuvant chemotherapy: 23 cases (1986-2000). J Am Vet Med
Alvarez FJ, et al. Treatment of dogs with stage III hemangiosarcoma
using the VAC protocol. J Am Anim Hosp Assoc. 2013;49(6):370. Assoc. 2005;226:575.
Bertazzolo W, et al. Canine angiosarcoma: cytologic, histologic, and Wirth KA, et al. In vitro effects of Yunnan Baiyao on canine hem-
immunohistochemical correlations. Vet Clin Pathol. 2005;34: angiosarcoma cell lines. Vet Comp Oncol. 2016;14:281.
28. Osteosarcoma
Boston SE, et al. Concurrent splenic and right atrial mass at pre- Alexander K, et al. A comparison of computed tomography, com-
sentation in dogs with HSA: a retrospective study. J Am Anim puted radiography, and film-screen radiography for the detection
Hosp Assoc. 2011;47:336. of canine pulmonary nodules. Vet Radiol Ultrasound. 2012;53:
Brown DC, et al. Single agent polysaccharopeptide delays metasta- 258.
ses and improves survival in naturally occurring hemangiosar- Boston SE, et al. Evaluation of survival time in dogs with stage III
coma. Evid Based Complement Alternat Med. 2012. osteosarcoma that undergo treatment: 90 cases (1985-2004). J
Ferrer L, et al. Immunohistochemical detection of CD31 antigen in Am Vet Med Assoc. 1905;228:2006.
normal and neoplastic canine endothelial cells. J Comp Pathol. Chun R, et al. Toxicity and efficacy of cisplatin and doxorubicin
1995;112:319. combination chemotherapy for the treatment of canine osteo-
Hammer AS, et al. Efficacy and toxicity of VAC chemotherapy (vin- sarcoma. J Am Anim Hosp Assoc. 2005;41:382.
cristine, doxorubicin, and cyclophosphamide) in dogs with hem- Fan TM, et al. Single-agent pamidronate for palliative therapy of
angiosarcoma. J Vet Intern Med. 1991a;5:16. canine appendicular osteosarcoma bone pain. J Vet Intern Med.
Lamerato-Kozicki AR, et al. Canine hemangiosarcoma originates 2007;21:431.
from hematopoietic precursors with potential for endothelial dif- Gordon IK, et al. Evaluation of the mammalian target of rapamycin
ferentiation. Exp Hematol. 2006;34:870. pathway and the effect of rapamycin on target expression and