Page 1367 - Small Animal Internal Medicine, 6th Edition

CHAPTER 81 Selected Neoplasms in Dogs and Cats 1339

VetBooks.ir Cancer Chemotherapy Protocols Commonly Used by the Authors—cont’d

VII. Mast cell tumors (nonresectable, systemic, or metastatic)
2
1. Prednisone: 40-50 mg/m PO q24h for 1 week; then 20-25 mg/m PO q48h
2
2. Lomustine (CCNU): 60 mg/m PO q3 weeks (with or without prednisone as in 1)
2
3. LVP protocol
2
Vinblastine: 2 mg/m IV q4-6 weeks alternating with
2
Lomustine (CCNU): 60 mg/m PO q4-6 weeks
2
Prednisone: 20-25 mg/m PO q48h
4. Toceranib (Palladia): 2.5 mg/kg, PO q48h
5. Masitinib (Kinavet): 10-12 mg/kg PO q24h
VIII. Soft tissue sarcomas—dogs
1. VAC protocol (21-day cycle)
2
Vincristine: 0.75 mg/m IV on days 8 and 15
2
Doxorubicin: 30 mg/m IV (or 1 mg/kg if < 10 kg) on day 1
2
Cyclophosphamide: 200-300 mg/m PO on day 10
Sulfa-trimethoprim: 15 mg/kg PO q12h
IX. Soft tissue sarcomas—cats
1. AC protocol (21-day cycle)
Doxorubicin: 1 mg/kg IV on day 1
Cyclophosphamide: 200-300 mg/m on day 10
2
2. MiC protocol (21-day cycle)
2
Mitoxantrone: 4-6 mg/m in IV drip over 4 hours on day 1
2
Cyclophosphamide: 200-300 mg/m PO on day 10
3. Carboplatin: 10 mg/kg IV q4 weeks
X. Osteosarcoma—dogs
1. Doxorubicin: 30 mg/m (or 1 mg/kg if < 10 kg) IV q2 weeks for 5 doses
2
2. Carboplatin: 300 mg/m IV q3 weeks for 4-6 doses
2
3. Doxorubicin and carboplatin as before, alternating drugs q3 weeks for 2-3 doses each
XI. Carcinomas—dogs
1. FAC protocol
2
5-Fluorouracil: 150 mg/m IV on days 8 and 15
2
Doxorubicin: 30 mg/m (or 1 mg/kg if < 10 kg) IV on day 1
2
Cyclophosphamide: 200-300 mg/m PO on day 10
Sulfa-trimethoprim: 15 mg/kg PO q12h
2. Carboplatin: 300 mg/m IV q3 weeks
2
3. Gemcitabine: 675 mg/m IV CRI for 30 minutes, q2 weeks
2
XII. Carcinomas—cats
5-Fluorouracil is toxic in cats, producing severe, and often fatal, central nervous system signs. Cisplatin is also
extremely toxic, causing acute pulmonary toxicity in this species.
1. Carboplatin: 10 mg/kg IV q4 weeks
2. AC protocol (21-day cycle)
Doxorubicin: 1 mg/kg IV on day 1
Cyclophosphamide: 200-300 mg/m PO on day 10
2
3. MiC protocol (21-day cycle)
Mitoxantrone: 4-6 mg/m IV CRI over 4 hours on day 1
2
2
Cyclophosphamide: 200-300 mg/m PO on day 10
4. MiCO protocol (21-day cycle)
Mitoxantrone: 4-6 mg/m IV CRI over 4 hours on day 1
2
Cyclophosphamide: 200-300 mg/m PO on day 10
2
2
Vincristine: 0.5-0.6 mg/m IV on days 8 and 15
XIII. Metronomic chemotherapy protocol
• Palladia (2.5 mg/kg, PO, Mon, Wed, Fri) plus
• Cyclophosphamide (10 mg/m , PO, Tue, Thu, Sat) or chlorambucil (2-4 mg/m , PO, Tue, Thu, Sat) plus
2
2
• A nonsteroidal antiinflammatory drug at therapeutic dosages plus
• Famotidine (0.5-1 mg/kg PO q24h)
CRI, Constant rate infusion; IM, intramuscularly; IV, intravenously; PO, orally; SC, subcutaneously.
*The daily dose should be divided into two to four daily administrations. The duration of chemotherapy using this protocol varies.