Page 1365 - Small Animal Internal Medicine, 6th Edition

CHAPTER 81 Selected Neoplasms in Dogs and Cats 1337

Lester S, et al. Vaccine-site associated sarcomas in cats: clinical Shaw SC, et al. Temporal changes in characteristics of injection-site
experience and a laboratory review (1982-1993). J Am Anim sarcomas in cats: 392 cases (1990-2006). J Am Vet Med Assoc.
VetBooks.ir Phelps HA, et al. Radical excision with five-centimeter margins for Shrivastav A, et al. Comparative vaccine-specific and other
Hosp Assoc. 1996;32:91.
2009;234:376.
treatment of feline injection-site sarcomas: 91 cases (1998-2002).
injectable-specific risks of injection-site sarcomas in cats. J Am
J Am Vet Med Assoc. 2011;239:97. Vet Med Assoc. 2012;241:595.
Romanelli G, et al. Analysis of prognostic factors associated with Wilcock B, et al. Feline postvaccinal sarcomas: 20 years later. Can
injection-site sarcomas in cats: 57 cases (2001-2007). J Am Vet Vet J. 2012;53:430.
Med Assoc. 2008;232:1193.
Scherk MA, et al. AAFP feline vaccination advisory panel report. J
Feline Med Surg. 2013;15(785):2013.

Cancer Chemotherapy Protocols Commonly Used by the Authors

1. Lymphoma
A. Induction of remission
1. COP protocol (8-week duration)
2
Cyclophosphamide: 50 mg/m PO q48h for 8 weeks in dogs; 200-300 mg/m PO q3 weeks in cats
2
2
Vincristine: 0.5 mg/m IV once per week for 8 weeks
2
2
Prednisone: 40-50 mg/m PO q24h for 1 week; then 20-25 mg/m PO q48h for 7 weeks
2. COAP protocol
2
Cyclophosphamide: 50 mg/m PO q48h or 300 mg/m PO q3 weeks*
2
Vincristine: 0.5 mg/m IV once per week
2
2
Cytosine arabinoside: 100 mg/m , IV or SC, divided q12h for 4 days
2
Prednisone: 40-50 mg/m PO q24h for 1 week; then 20-25 mg/m PO q48h
2
In cats, cytosine arabinoside is administered for only 2 days and the remaining three drugs (cyclophosphamide,
vincristine, prednisone) are administered for 6 weeks rather than 8 weeks.
3. CLOP protocol
As in COP protocol but with the addition of L-asparaginase at a dosage of 10,000-20,000 IU/m IM q4-6 weeks
2
4. UW-25 protocol (This protocol uses no maintenance chemotherapy—for additional information please see text)
Week 1: Vincristine: 0.5-0.75 mg/m IV
2
Prednisone: 40 mg/m PO q24h
2
Week 2: Cyclophosphamide: 200-250 mg/m , IV or PO
2
Prednisone: 30 mg/m PO q24h
2
2
Week 3: Vincristine: 0.5-0.75 mg/m IV
2
Prednisone: 20 mg/m PO q24h
2
Week 4: Doxorubicin: 30 mg/m (or 1 mg/kg if < 10 kg) IV
2
Prednisone: 10 mg/m PO q24h
Week 5: No treatment—discontinue prednisone if CR
Week 6: Vincristine: 0.5-0.75 mg/m IV
2
Week 7: Cyclophosphamide: 200-250 mg/m , IV or PO
2
2
Week 8: Vincristine: 0.5-0.75 mg/m IV
2
Week 9: Doxorubicin: 30 mg/m (or 1 mg/kg if < 10 kg) IV
Week 10: No treatment
Week 11: Vincristine: 0.5-0.75 mg/m IV
2
2
Week 13: Cyclophosphamide: 200-250 mg/m , IV or PO
2
Week 15: Vincristine: 0.5-0.75 mg/m IV
Week 17: Doxorubicin: 30 mg/m (or 1 mg/kg if < 10 kg) IV
2
Week 18: No treatment
Week 19: Vincristine: 0.5-0.75 mg/m IV
2
2
Week 21: Cyclophosphamide: 200-250 mg/m , IV or PO
Week 23: Vincristine: 0.5-0.75 mg/m IV
2
Week 25: Doxorubicin: 30 mg/m (or 1 mg/kg if < 10 kg) IV
2
B. Maintenance
1. LMP protocol
Chlorambucil: 20 mg/m PO q2 weeks
2
2
Prednisone: 20-25 mg/m PO q48h
2
Methotrexate: 2.5-5 mg/m PO 2 or 3 times per week
Continued