Page 1366 - Small Animal Internal Medicine, 6th Edition

1338 PART XII Oncology

VetBooks.ir Cancer Chemotherapy Protocols Commonly Used by the Authors—cont’d

2. CCNU/Prednisone protocol
CCNU (lomustine): 60-70 mg/m PO q3 weeks
2
Prednisone: 20-25 mg/m PO q48h
2
3. LAP protocol
Chlorambucil: 20 mg/m PO q2 weeks
2
Prednisone: 20-25 mg/m PO q48h
2
2
Cytosine arabinoside (Cytosar): 200-400 mg/m SC q2 weeks; alternating with chlorambucil
4. COP protocol used every other week for 6 cycles; then every third week for 6 cycles; then monthly thereafter
C. “Rescue”
DOGS
1. D-MAC protocol (14-day protocol; repeat continuously for 10-16 weeks)
Dexamethasone: 0.5 mg/lb (1 mg/kg) PO or SC on days 1 and 8
2
Actinomycin D (Cosmegen): 0.75 mg/m IV push on day 1
2
Cytosine arabinoside (Cytosar): 200-300 mg/m IV drip over 4 hours or SC on day 1
2
Melphalan (Alkeran): 20 mg/m PO on day 8 (after 4 doses of melphalan, substitute chlorambucil at the same
dose)
2. MOPP protocol (28-day protocol; repeat continuously until relapse)
Mechlorethamine: 3 mg/m IV on days 0, 7
2
2
Vincristine: 0.7 mg/m IV on days 0, 7
Procarbazine: 50 mg/m PO q24h for days 0-13
2
2
Prednisone: 30-40 mg/m PO q24h for days 0-13
3. L-asparaginase, CCNU, and prednisone
CCNU (lomustine): 70 mg/m PO q3 weeks
2
L-asparaginase: 400 u/kg SC or IM q3 weeks
Prednisone: 2 mg/kg PO q24h, taper when remission obtained
4. Dacarbazine: 800-1000 mg/m q14-21 days
2
5. CCNU (lomustine): 60-80 mg/m q21 days
2
6. Rabacfosadine: 0.82-1 mg/kg IV over 30 minutes q3 weeks
CATS
1. ACD protocol (21-day cycle)
Doxorubicin: 1 mg/kg IV on day 1
Cyclophosphamide: 200-300 mg/m PO on day 10
2
Dexamethasone: 4 mg/cat PO q1-2 weeks
2. AMD protocol
Cytosine arabinoside: 100-200 mg/m /day IV CRI for 1-2 days
2
2
Mitoxantrone: 4 mg/m in IV CRI, mixed in the bag with the cytosine arabinoside
Dexamethasone: 0.5-1 mg/lb (1-2 mg/kg) PO weekly; repeat q3 weeks
3. CCNU: 10 mg/cat q3-6 weeks
II. Acute lymphoid leukemia (ALL)
COAP, CLOP, COP, or CHOP protocols
III. Chronic lymphocytic leukemia (CLL)
2
1. Chlorambucil: 20 mg/m PO q2 weeks (with or without prednisone, 20 mg/m PO q48h)
2
2
2. Cyclophosphamide: 50 mg/m PO q48h, and prednisone: 20 mg/m PO q48h
2
IV. Acute myelogenous leukemia
1. Cytosine arabinoside: 5-10 mg/m SC q12h for 2-3 weeks; then on alternate weeks
2
2. Cytosine arabinoside: 100-200 mg/m in IV CRI over 4 hours
2
Mitoxantrone: 4-6 mg/m in IV CRI over 4 hours; repeat every 3 weeks
2
V. Chronic myelogenous leukemia
1. Hydroxyurea (Hydrea): 50 mg/kg PO q24-48h until normal white blood count
VI. Multiple myeloma
1. Melphalan (Alkeran): 2-4 mg/m PO q24h for 1 week; then q48h. Can also be given at 6-8 mg/m PO for 5
2
2
days, repeating every 21 days
2
Prednisone: 40-50 mg/m PO q24h for 1 week, then 20 mg/m PO q48h
2
2. As in III.2