Page 112 - Veterinary Immunology, 10th Edition
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FIG. 4.11 Substrate modulation is one way in which the
complement system is regulated. The target for a protease cannot
be cleaved unless it is first bound to another protein. Examples of
substrate modulation include the cleavage of factors C2, B, and C5
only after they have bound to C4, C3, and C3, respectively.
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