Page 288 - Veterinary Immunology, 10th Edition

VetBooks.ir Dendritic Cells in Domestic Animals

DCs are found in all the major domestic mammals and do not
appear to differ in any significant respect from DCs in humans and

mice. In domestic animals, cDCs have been characterized in horses,
ruminants, pigs, dogs, and chickens, whereas Langerhans cells have
been described in horses, ruminants, pigs, dogs, and cats. pDCs
have been characterized in pigs and horses.
Horses: Equine DCs express MHC class II, CD11, EqWC1, and

EqWC2. Different subsets have been identified based on their
expression of MHC class II and other markers. Equine pDCs have
been characterized and shown to produce large amounts of IFN-α

on stimulation with TLR9 agonists.
Ruminants: Bovine DCs express MHC II, CD80, CD86, and CD40
(Fig. 10.8). Cattle possess two dendritic cell subpopulations that
differ in their ability to stimulate CD4 and CD8 T cells. One
population synthesizes more IL-12, whereas the other population

produces more IL-1 and IL-10. These may well represent cDC1 and
cDC2 subpopulations. Cattle also possess some DCs that produce
large amounts of type I interferons and are therefore likely

functional equivalents of pDCs.

FIG. 10.8 A transmission electron micrograph of a dendritic cell
from bovine afferent lymph. It has been stained with a monoclonal
antibody specific for bovine CD1b. (The antibody is linked to
colloidal gold particles, which are visible as small, electron dense
dots around the outside of the cell). (Courtesy Dr. C.J. Howard and Dr. P.

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