Page 369 - Veterinary Immunology, 10th Edition

Splenic follicles Spleen periarteriolar sheath
VetBooks.ir Antigen receptors BCR—immunoglobulin TCR—protein heterodimer
No
Circulate
Yes
Associated with CD3, CD4, or CD8
Important surface
antigens Immunoglobulins CD2, CD3, CD4, or CD8
Mitogens Pokeweed, lipopolysaccharide Phytohemagglutinin, concanavalin A, BCG vaccine,
pokeweed
Antigens recognized Free foreign proteins Processed foreign proteins in MHC antigens
Tolerance induction Difficult Easy
Progeny cells Plasma cells, memory cells Effector T cells, memory T cells
Secreted products Immunoglobulins Cytokines
The loss of cell-mediated immunity as a result of neonatal
thymectomy first demonstrated the existence of T cells (Fig. 13.6).
After T cells leave the thymus, they accumulate in the paracortex of

lymph nodes, the periarteriolar lymphoid sheaths of the spleen, and
the interfollicular areas of the Peyer's patches. T cells also account
for 60% to 80% of the lymphocytes in blood (Table 13.2).

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