Page 12 - IJCS Journal Vol.1.cdr

theijcs.com The IJCS / Vol 1 / Issue 1

Circadian rhythm gene PER3 gene in relation with
ovarian cancer patients of Jammu region

a
b
a
Sonali Verma , Ajay Wakhloo , V.Verma , Rakesh Kumar *
Contributing Authors Affiliations:
a) School of Biotechnology, Shri Mata Vaishno Devi University
b) Department of obestrics and Gynaecology, SMGS hospital Jammu.
Correspondence email: Kumar.rakesh@smvdu.ac.in

Abstract

Introduction
Copy number variants (CNVs) have been associated with many cancers. We examined that CNVs were associated
with overall survival among women with invasive epithelial ovarian cancer.

Material and Method
Germline DNA from ovarian cancer patients and normal females was investigated with the Illumina for exome
sequencing, after quality control exclusions.

Results
After exome sequencing about 581,003 single nucleotide polymorphisms (SNPs) and 1500 CNV's were identified. In
this study, the single CNV marker (PER3) at chromosomal position 1q11 was evaluated, where patients positive for

mutation of PER3 gene having genetic variant rs228696 on cox regression analysis by using covariates (mutational
status and age) showing a strong association between mutational status and Ovarian cancer patients with a significant
p value <0.005 at 95% CI, hazard ratio of 4.5(1.3- 14.6).

Conclusion and discussion
It was reported that the disruption in metabolism has strong correlation with circadian clock genes (PER) (Jim et al.,
2015) these genes also showed strong association with ovarian cancer (Qu et al., 2016). The findings of our study

intimate us about the role of PER3 variant rs228696 in ovarian cancer patients.

Corresponding Author
Dr Sonali Verma
School of Biotechnology, Shri Mata Vaishno Devi University
Correspondence email: Kumar.rakesh@smvdu.ac.in

The Integrated Indian Journal of Cancer Sciences