Page 153 - Medicinal Chemistry Self Assessment
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7. Shown below are or a phase II transformation.
Metabolite A
Metabolite B
Metabolite C
Answer
Metabolite A: Aromatic oxidation, phase I
Metabolite B: Benzylic oxidation, phase I
142 Note: Due to the ability to form a conjugated system, this secondary hydroxyl group readily
Medicinal Chemistry Self Assessment
undergoes dehydration to form the following metabolite.
Dehydration allows
conjugation between
the amide and the
aromatic ring.
Metabolite C: Oxidative N-dealkylation followed by oxidation of the resulting aldehyde to a carbox-
ylic acid by aldehyde dehydrogenase, phase I
Go to Section 1.9 [Link to section 1.9 title]
