Page 160 - Medicinal Chemistry Self Assessment

Section 4 Whole Molecule Drug Evaluation

Answers

2.11 Cetirizine

Cetirizine is a popular second-generation antihistamine used in the management of allergy symptoms. It is the
Medicinal Chemistry Self-Assessment Book: Batch Two
metabolic byproduct produced from the prescription antihistamine hydroxyzine. Although cetirizine is labeled as
Chapters 1.11 and 2.11
non-sedating and is one of the preferred allergy medications for long-haul drivers, hydroxyzine causes significant

drowsiness that limits its utility in the management of typical allergy symptoms. Hydroxyzine is commonly used in
Chapter 1.11 (remove bolded drug names)
the treatment of pruritus (severe itching).

Cetirizine
Hydroxyzine

1. Conduct a complete structural evaluation of hydroxyzine and use the information in the grid to inform
Chapter 2.11 (remove bolded drug names)
your answers to the questions that follow.

A C D E

B Hydroxyzine

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