Page 20 - Medicinal Chemistry Self Assessment

1.2 Identifying Acidic and Basic Functional Groups 9

6. For each of the drug molecules shown below, determine if it is an acidic drug molecule, a basic drug molecule,
6. For each of the drug molecules shown below, determine if it is an acidic drug molecule, a basic drug
an amphoteric drug molecule, or a nonelectrolyte.
molecule, an amphoteric drug molecule, or a nonelectrolyte.

O NH O COOH
CF 3
N
H H 2 N N N
H
N O S NH CH
O H 3
N
N
Lomitapide H O
CF 3
CH 3
Argatroban

H O OCH
COOH 3
OH
O
H O NH
H 3 C O H Cl N N NH S
CH 3 CH 3 H 2 O CH 3
H 2 N N NH 2 N
O O
H O Amiloride
CH N(CH )
Pravastatin 2 3 2
Diltiazem

Drug Molecule Acid/Base Character of Drug Molecule
Lomitapide
Argatroban

Pravastatin
Amiloride
Diltiazem

Answers can be found in Section 2.2 [this will be linked to section 2.2 title] Page 2 of 2
Note: The questions in this chapter are related to Chapter 3 in Harrold MW and Zavod RM, Basic Concepts in
Medicinal Chemistry, American Society of Health-System Pharmacists, ©2013.