Page 248 - Medicinal Chemistry Self Assessment

Answer:
A. Hydrolysis: Phase I oseltamivir.

Ester hydrolysis
Amide hydrolysis
hydrolysis

B. Allylic oxidation: Phase a hydrogen atom that is required for oxidation.

Already attached
to a heteroatom
Lacks a hydrogen atom Ester and amide
Already attached
to a heteroatom Oseltamivir
2.27 Zanamivir and Oseltamivir 237

C. Glucuronide conjugation: Phase II.
c. Glucuronide conjugation: Phase II transformation. It can occur directly with the secondary amine
or with the carboxylic acid that results from phase I ester hydrolysis.

D. Oxidation: Phase I, Yes

D. Oxidation: Phase I, Yes

d. ω-Oxidation: Phase I, Yes

E. Oxidative O-Dealkylation: Phase I, Yes
e. Oxidative O-Dealkylation: Phase I, Yes

E. Oxidative O-Dealkylation: Phase I, Yes

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