Page 250 - Medicinal Chemistry Self Assessment

Index

A Angiotensinogen, 27, 129 C
Anticholinergic agents, 18, 114-115
Acebutolol, 21, 117-119 Antidiabetic agent, experimental, 7-8, 99, C-11 oxidation, 58, 179
Acetylcholine, 79-80, 218-219 101, 102 C-17 oxidation, 58, 179
Acetylcholinesterase inhibitor, 79-81, Antihistamine, 39, 149-152 C-21, 60, 179-180
218-221 Cahn-Ingold-Prelog (CIP) system, 22,
Acidic functional group, 7-9, 11-12, 31, 36, Anti-hyperlipidemic agents, 47, 165 119-120, 184
40, 55, 66, 69, 75, 81, 91, 99-103, Anxiolytic effect, 53, 172 Carbamate group, 81, 219-220
105-106, 137, 151, 155, 174, 190, Arformoterol, 13-14, 109
193-194, 211-212, 233 Argatroban, 9, 103 Carboxylic acid, 73, 185, 194, 206
Action Arginine, 8, 102 Cefamandole, 21, 117-119
duration of, 81, 220 Aripiprazole, 31-33, 137-142 Cefotaxime, 11, 105-106
onset, 66, 190 metabolites, 33, 141 Cefprozil, 35-38, 143-147
Active metabolite, 63, 186-187 Aromatic oxidation, 70, 141, 197 Cephalosporin, 35, 143
Active product, 58-59, 179 Aspartic acid, 88, 98, 228 Cetirizine, 39-40, 149-152
Adenosine triphosphate (ATP) binding, 87, Atenolol, 11, 105, 105-106 Chemical hydrolysis, 147
227 Atrial fibrillation, 43, 159 Chiral carbon atom, 62, 184
Administration routes, 14-15, 109-110 Chiral centers, 21-22, 119
Alanine, 87, 227 B Chlorimipramine, 24, 124
Alendronate, 15, 111 Baclofen, 13-14, 24, 109, 129 Chlorpropamide, 41-42, 153-157
Aliskiren, 27-30, 129-135 Ciprofloxacin, 13-14, 109
Barbiturates, 71-72, 199-203
Allylic oxidation, 92, 236 Barbituric acid, 199 Class IB anti-arrhythmic agent, 65, 189
Alprazolam, 53, 172 Clonidine, 8, 102-103
Basic functional group, 7-9, 11, 12, 31, 36,
Amiloride, 9, 103 40, 55, 69, 75, 91, 99-103, 105-106, CNS-based toxicities, 67, 192
Amino acid binding interactions, 32, 139-140 137, 144, 151, 155, 174, 193-194, Conformational isomer, 92, 235
Amino acid side chain interactions, 30, 44-45, 211-212, 233 Conjugate elimination, 48, 168
56, 58, 72, 88, 134, 163, 175, 178, Benzodiazepines, 53, 172 Cucumber flavor, 20, 116
201-202, 228-229, 230 Benzylic oxidation, 56, 70, 141, 176, 191, Cysteine, 88, 228
Amino acid-based hormone, 62, 185 198 Cysteinyl leukotriene receptors, 70, 196
Amino acids, 5, 98 Beta-lactam bond instability, 38, 147
Amlodipine, 30, 134-135 Beta-lactamases, 38, 147 D
Amphoteric drug, 9, 36, 103, 144 Binding interactions, 56, 175
Dabigatran etexilate, 43-45, 159-164
Anesthetic, 65, 189 Bioavailability, 132 mesylate, 45, 164
Angiotensin converting enzyme, 27, 129 Biological targeting, 14-15, 19, 110, 115
Dehalogenation, 61, 63, 183, 186-187
Angiotensin converting enzyme (ACE) Blood soluble, 65, 190 Delapril, 17, 113
inhibitor(s), 17, 75-78, 113, 211-215 Bromfenac, 3, 7-8, 37, 99, 101, 102
Angiotensin I, 27, 77, 129-130, 213 Butabarbital, 71, 199-200 Depot injections, 60, 180
Angiotensin II, 27, 129-130 metabolite, 72, 202-203 Dexfenfluramine, 24, 125
Angiotensin II receptor blockers (ARBs), 41, Diastereomer(s), 21, 28, 52, 62, 92, 117-119,
130-131, 170, 184, 235
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