Page 88 - Medicinal Chemistry Self Assessment

Chapter 1.23
Please replace the structure for Question 2 in Chapter 1.23 with the one shown below. (NOTE: The analogous
structure in Chapter 2.23 is fine.)

Chapters 1.23 and 2.23
Please replace the structures for Angiotensin I and Quinaprilat in Question 4 for both 1.23 and 2.23 with the one
provided below. 1.23 Quinapril 77
5. Quinapril inhibits ACE. This at a pH of 7.4.

Leu Leu

Phe
Phe His His
Quinaprilat
Quinaprilat
Angiotensin I
Angiotensin I
R = Asp-Arg-Val-Tyr-Ile-His
R = Asp-Arg-Val-Tyr-Ile-His-Pro

6. Shown below are in these pathways.

5. Shown below are four possible metabolic pathways for quinapril. Identify the metabolic transforma-
tions involved in these pathways.

A B

Quinapril

C D