Page 171 - PG 101-Course notes مذكرة النظري 24-25 with spec
P. 171
Medicinal plants (PG 101) Level 1 Clinical Pharmacy-PharmD
Acetyl-CoA, enters the cycle, charging NADH and ATP. In the case of the Krebs
cycle, another battery molecule, FAD, is charged, making FADH2.
The Krebs cycle is a series of ten enzymatic reactions.
Each molecule of Acetyl-CoA combines with the oxaloacetate (4 carbon) to
make Citric acid. Citric acid has six carbons.
In a series of five (5) enzymatic reactions, Citric acid has two more CO2 split off,
+
and charges NAD into NADH.
We now have a 4-carbon molecule called succinyl-CoA. Succinyl-CoA now runs
through two more reactions to produce ATP, FADH2, and an energy reduced 4-
carbon compound. At the end of the Krebs cycle, one last bit of energy is squeezed
out of the 4-carbon compound, producing NADH and oxaloacetate.
✓ Finally, oxaloacetate is recycled back into the Krebs cycle, being energized by
another Acetyl-CoA. The Krebs cycle is summarized below.
142