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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

▪ As anti-acid: Due to the present amino-groups, chitosan can act as anti-acid

and is beneficial in the healing of ulcers and lesions.

▪ Stop bleeding, bacteriostatic: Chitin/Chitosan Biomedical Dressing (Stop

bleeding, bacteriostat.

▪ Recently: Chitosan is used as a delivery vehicle for pharmaceuticals and genes

▪ N.B.: Glucosamine sulphate (see above): It is assumed to restore normal

cartilage.

Simple acid mucopolysaccharides / or Glycosaminoglycans (GAG)

Polysaccharide containing [URONIC ACID + AMINO SUGAR] n
Acetylated amino-sugar units, sulfate, and carboxyl group may be present also.

a. Hyaluronic acid b. Chondroitin sulfate c. heparin

Hyaluronic acid

Structure: D-glucuronic acid, N-acetylglucosamine

• Hyaluronidase is an enzyme that breaks β 1 –4 linkages of hyaluronic acid.

• Present in high concentration in seminal fluid to degrades the gel around ovum

& allows effective penetration of sperm into ovum, thus helps in fertilization.

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