Page 126 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

• The α-hydroxy aldehyde function is a center of instability such that

streptomycin cannot be sterilized by autoclaving, but instead sterilized by

ultrafiltration.

b) 2-deoxystreptamine aminoglycosides

1. Kanamycin

Kanamycins A, B, C: Antibiotic complex from Streptomyces kanamyceticus.

Kanamycin is stable when heated with acid or alkaline solutions and even

withstand autoclaving.

• It is used parentrally against gram-negative bacteria but Pseudomonas

aeruginosa and anaerobes are usually resistant.

• Its injections are painful and sometimes require a local anesthetic.

• Available in oral, intravenous, and intramuscular forms.

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