Page 44 - Practical Technology 2025

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Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)

➢ Official and Unofficial Tests

• Official Tests (The standards that are found in the BP and USP including:)

• Weight variation, uniformity of diameter, disintegration, dissolution and drug content.
• Non-Official Tests (non-pharmacopoeial standards):

• Hardness, friability and uniformity of thickness.

I) Determination of Tablet Diameter:

❖ Materials: 10 tablets

❖ Apparatus: Ruler

Uniformity of tablet diameter follows the pharmacopoeial standard if:

All of the percentage average deviation value not exceed ± 5% for tablets with

average diameter less than 12.5 and ± 3% for average diameter of 12.5 mm or more.

Rules:

Deviation = diameter of each tablet - Average diameter

−
% Deviation = [ ] X 100

Example:

Tablet Diameter Tablet Diameter % Tablet Diameter
Tablet no.
(mm) Deviation Deviation
1 12.82

2 12.81

3 12.79
4 12.84

5 12.82

6 12.84

7 12.82
8 12.83

9 12.80

10 12.82

Average

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