Page 45 - Practical Technology 2025
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Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)
Discussion
The average diameter = ……………. mm, So, ……………………………………....
……………………………………………………………………………………………
……………………………………………………………………………………………
II) Determination of Tablet Thickness:
❖ Apparatus: Vernier Caliber
- Tablets thickness should be controlled with no more than ± 5% of a standard
value.
- Any variation in tablet thickness should not be apparent to the unaided eye to
maintain product acceptance by consumer as well as to facilitate packaging.
- At constant compressive load, tablet thickness varies with changes in die fill and
tablet weight, Whereas, with a constant die fill, thickness varies in variation in
compressive load.
Three set of factors influence tablet thickness and tablet thickness control:
1- The physical properties of raw materials including crystal form and true density.
2- Control of upper and lower punch lengths, which should be standardized.
3- The granulation properties including bulk density, tapped density, particle size, and
particle size distribution.
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