Page 79 - Practical Technology 2025
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Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)
Causes Remedies
Inefficient drying. Use efficient and optimum drying
conditions.
Higher rate of application of coating Increase viscosity of coating solution
solution. to decrease spray application rate
3- Blooming
It is defect where coating becomes dull immediately or after prolonged storage
at high temperatures.
Causes Remedies
High concentration and low Decrease plasticizer concentration
molecular weight of plasticizer used and increase molecular weight of
in the coating solution. plasticizer.
4- Blushing:
It is a defect best described as whitish specks or haziness in the film.
Causes Remedies
High coating temperature. Decrease the drying air temperature.
Use of sorbitol in formulation which Avoid use of sorbitol with
causes rapid precipitation of the Hydroxy Propyl Cellulose, Hydroxy
Hydroxy Propyl Cellulose, hydroxy Propyl Methyl Cellulose, Methyl
Propyl Methyl Cellulose, Methyl Cellulose and Cellulose ethers.
Cellulose and Cellulose ethers.
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