Page 74 - Practical Technology 2025

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Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)

The causes and remedies of cracking
a. Causes related to formulation (granulation):

Causes Remedies

Large size of granules Reduce granule size. Add fines.

Too dry granules. Moisten the granules properly and

add proper amount of binder.

Granulation too cold. Compress at room temperature.

b. Causes related to machine:

Causes Remedies

Deep concavities cause cracking Use tapered die. The use of a tapered

while removing tablets die, which essentially minimizes the
interaction of the die edge with the

expanding compact, can help to

minimize damage

3- Chipping:
Defined as the breaking of tablet edges, while the tablet leaves the press or

during subsequent handling and coating operations.

Reason: Incorrect machine settings, especially miss-set ejection take-off.

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