Page 72 - Practical Technology 2025

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Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)

Lab (9): Troubleshooting problems during tablet manufacture

1- Capping and lamination

Capping is the horizontal separation of upper or lower segment of the tablet,

either partially or completely from the main body of the tablet and comes off as

a cap, during ejection from the tablet press, or during subsequent handling.

Lamination is the separation of a tablet into two or more distinct horizontal

layers.

Capping Lamination

The causes and remedies of capping and lamination

a. Causes related to formulation (granulation):

Causes Remedies

Large amount of fines in the Remove some or all fines through 100
granulation. to 200 mesh screen.

Too dry or very low moisture Moisten the granules suitably.
content (leading to loss of proper Add hygroscopic substance e.g.:
binding action). sorbitol, methyl- cellulose or
PEG4000.
Insufficient amount of binder or Increasing the amount of binder.
improper binder.

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