Page 12 - ASME_NEMB_2016_Program

Plenary Sessions

PLENARY TITLE: NICHOLAS A. PEPPAS: NANO-ENGINEERING MRS, SFB, BMES, AIMBE, CRS, AAPS, and ASEE. He has supervised the
INTELLIGENT AND DIAGNOSTIC THERAPEUTIC SYSTEMS research of 100 PhDs and about 180 postdocs and graduate students.
Date/Time: Sunday, February 21, 04:00-04:45 PM Peppas holds a Dipl. Eng. from the NTU of Athens (1971), a Sc.D. from MIT
Location: Grand Ballroom (1973), and honorary doctorates from the Universities of Ghent, Parma,
Presenter: Nicholas A. Peppas, University of Texas, Austin Athens, Ljubljana, Patras and Sichuan.

Session Description: Engineering the molecular design
PLENARY TITLE: THERMAL CONTRAST AND NANOWARMING:
of intelligent biomaterials by controlling recognition
HOW NANOPARTICLE HEATERS ARE IMPROVING DIAGNOSTICS
and specificity is the first step in coordinating and
AND REGENERATIVE MEDICINE
duplicating complex biological and physiological
Date/Time: Monday, February 22, 08:30-09:15 AM
processes. Recent developments in protein delivery have been directed
Location: Grand Ballroom
towards the preparation of targeted formulations for protein delivery to
Presenter: John C. Bischof, University of Minnesota
specific sites, use of environmentally-responsive polymers to achieve pH- or
temperature-triggered delivery, usually in modulated mode, and improve-
Session Description: Gold and magnetic nanoparticles
ment of the behavior of their mucoadhesive behavior and cell recognition.
have unique and tunable properties that allow
We address design and synthesis characteristics of novel crosslinked
transduction of optical (light), or radiofrequency (RF)
networks capable of protein release as well as artificial molecular structures
electromagnetic fields to affect heating of biomaterials
capable of specific molecular recognition of biological molecules. Molecular
at multiple scales. This talk will explore the underlying
imprinting and microimprinting techniques, which create stereo-specific
physics and relative advantages of each form of nanoparticle heating and
three-dimensional binding cavities based on a biological compound of
then introduce several applications. First, laser heating of gold nanoparti-
interest can lead to preparation of biomimetic materials for intelligent drug
cles is used to achieve an order of magnitude improvement in sensitivity
delivery, drug targeting, and tissue engineering. We have been successful
for common point-of-care (POC) diagnostic assays (i.e. a lateral flow
in synthesizing novel glucose- and protein-binding molecules based on
immunoassay or LFA) through “thermal” vs. visual contrast. This increase
non-covalent directed interactions formed via molecular imprinting
in sensitivity addresses the main weakness of the LFA, increasing
techniques within aqueous media.
opportunities for use in POC settings and avoiding the cost, time and labor
of laboratory tests. Second, RF heating of magnetic nanoparticles
Bio: Nicholas A. Peppas is the Cockrell Family Regents Chaired Professor
deployed within biomaterials can be used for improved cancer hyperther-
in the Departments of Chemical, Biomedical Engineering and Pharmacy
mia and regenerative medicine. For instance, in regenerative medicine,
and Director of the Institute of Biomaterials, Drug Delivery and Regenera-
“nanowarming” by this method can heat vitrified biomaterials at a
tive Medicine of the University of Texas at Austin. From 2009 to 2015 he
sufficiently rapid and uniform rates to avoid crystallization and cracking,
was also the Chairman of the Department of Biomedical Engineering . His
thereby addressing an important technology bottleneck. In summary, this
work in biomaterials, polymer physics, drug delivery and bionanotechnolo-
talk demonstrates the growing opportunities for nanoparticle heating in
gy follows a multidisciplinary approach by blending modern molecular and
biomedical applications.
cellular biology with engineering principles to design the next-generation
of medical systems and devices for patient treatment. Over the past 40
Bio: Bischof’s area of research is in thermal bioengineering with a focus on
years he has set the fundamentals and rational design of drug delivery
biopreservation, thermal therapy and nanomedicine. Awards and
systems and developed models of drug and protein diffusion in controlled
recognition for his work include: the ASME Van Mow Medal; several
release devices and biological tissues. In 2012 he received the Founders
“Career,” “First” and “Young Investigator” Awards from the NSF, NIH and
Award of the National Academy of Engineering (NAE), the highest
Whitaker Foundation; and Fellowships in AIMBE, ASME, Society for
recognition of the Academy, for these contributions to the field. Peppas is
Cryobiology, Alexander von Humboldt, and the Japan Society for the
a member of the NAE, National Academy of Medicine (NAM), National
Promotion of Science (JSPS). He has served as the President of the
Academy of Inventors (NAI), the National Academy of France, the Royal
Society for Cryobiology and Chair of the Bioengineering Division of the
Academy of Spain, the Academy of Athens and the Academy of Texas. He
ASME.
has been recognized with awards from AIChE (Founders Award, William
Walker Award, Institute Lecture, Jay Bailey Award, Bioengineering Award, Bischof obtained a B.S. in Bioengineering from U.C. Berkeley (UCB) in
Materials Award), the Biomedical Engineering Society (Distinguished 1987, an M.S. from UCB and U.C. San Francisco in 1989 and a Ph.D. in
Scientist Award), the American Institute of Medical and Biological Mechanical Engineering from UCB in 1992 under Boris Rubinsky. After a
Engineering (Galletti Award), the Society for Biomaterials (Founders, Post-doctoral Fellowship at Harvard in the Center for Engineering in
Clemson and Hall Awards), the Controlled Release Society (Founders, Medicine under Mehmet Toner he joined the University of Minnesota in
Heller and Eurand Awards) and other societies. In 2008, AIChE named him 1993. Bischof is now a Distinguished McKnight University Professor in the
on of the One Hundred Chemical Engineers of the Modern Era. He is Departments of Mechanical and Biomedical Engineering, the inaugural
President of the International Union of Societies of Biomaterials Science Carl and Janet Kuhrmeyer Chair in Mechanical Engineering and the
and Engineering, Past-Chair of the Engineering Section of the American Associate Head of the Institute for Engineering in Medicine at the
Association for the Advancement of Science, and Past-Chair of the Council University of Minnesota.
12 of BME Chairs. Previously, he served as President of SFB and the
Controlled Release Society. He is a fellow of AAAS, AIChE, APS, ACS,