Page 16 - ASME_NEMB_2016_Program

Technical Program TRACK 1

synthesis of intrinsically radiolabeled nanoparticles have shown its attractive gy, Pohang, Korea (Republic), Jonathan Lovell, University at Buffa-
potential in offering an easier, faster, more stable, and more specific radiola- lo, Buffalo, NY, United States
beling for the next generation of molecular imaging.
There is a need for safer and improved methods for non-invasive imaging
10:20am Renal Clearable Luminescent Metal Nanoparticles for of the gastrointestinal tract. Here, we report the development of a family of
Biomedical Imaging nanoparticles that can withstand the harsh conditions of the stomach and
intestine, avoid systemic absorption, and provide good optical contrast for
Technical Presentation. NEMB2016-5932 photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was
exploited to generate frozen micelles (nanonaps), with tunable near-infrared
absorption. Nanonaps, following oral administration in mice, passed safely
Jie Zheng, The University of Texas at Dallas, Richardson, TX, Unit- through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic
ed States techniques were used to visualize nanonap intestinal distribution with low
background and remarkable resolution, and enabled real-time intestinal
While inorganic nanoparticles with size-dependent material properties open functional imaging with ultrasound co-registration. Positron emission tomog-
up unprecedented opportunities for novel biomedical technologies, trans- raphy following seamless nanonap radiolabelling allowed complementary
lation of these nanoparticles into clinical practices has been hampered by whole-body imaging.
the potential toxicity resulted from their long-term nonspecific accumulation
in healthy tissues. Emergence of renal clearable inorganic nanoparticles
makes it possible to address this long-term challenge. In the past few
years, we used glutathione, a tri-amino-acid peptide to stabilize 2-3nm gold 1-2
nanoparticles, which can give different colored luminescence upon their va- MRI, MULTI-MODAL, AND THERANOSTIC NANOPARTICLES
lence states of gold atoms (1). These glutathione coated gold nanoparticles
(GS-AuNPs) have little interactions with serum proteins; and more impres-
sively, they can be cleared from the body through kidneys with an efficiency Sam Houston 11:30 AM - 1:00 PM
of 10-100 times better than the same sized AuNPs (2) and exhibit unique mo-
lecular-like pharmacokinetics (3). By further modifying the surface chemistry, Session Organizer: Jonathan Lovell, University at Buffalo, Buffalo,
we found that these NPs can be successfully tuned to avidly target cancer NY, United States
cell membrane under mild acidic conditions (6.5 - 5.3) even in the presence
of serum proteins (4). More recently, we found that they can passively target 11:30am Fluorine Magnetic Resonance Imaging with Perfluoro-
19
the MCF-7 breast cancer through enhanced permeability and retention (EPR)
effect (5), which can be further enhanced through PEGylation (6). No limited carbon Nanoparticles
to cancer imaging, noninvasive fluorescence kidney functional imaging can
also be achieved with these renal clearable luminescent metal NPs (7). This Keynote. NEMB2016-5929
new class of renal clearable AuNPs holds great promise to address chal-
lenges in biomedical imaging (8,9). Gregory Lanza, Washington University School of Medicine, St. Lou-
is, MO, United States
References
(1) Zheng, J.; Zhou, C.; Yu, M.; Liu, J.; Nanoscale, 2012, 4, 4073 19 Fluorine ( F) magnetic resonance imaging (MRI) has its research roots
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(2) Zhou, C.; Long, M.; Qin, Y.; Sun, X.; Zheng, J.; Angew. Chem. Int. Ed., 2011, dating back over 35 years. Over that time span, H imaging flourished and
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50, 3168 was adopted throughout the world with an endless array of applications and
(3) Zhou, C.; Hao, G.; Patrick, T.; Liu, J.; Yu, M.; Sun, S.; Oz, O.; Sun, X.; Zheng, imaging approaches, making MR an indispensible pillar of biomedical diag-
J.; Angew. nostic imaging. For many years during this timeframe, F imaging research
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Chem. Int. Ed., 2012, 51, 10118 continued at a slow pace as the various attributes of the technique were
(4) Yu, M.; Zhou, C.; Liu, J.; Hankins, J. D.; Zheng, J.; J. Am. Chem. Soc., 2011, explored. However, over the last decade and particularly the last several
133,11014 years, the pace and clinical relevance of F imaging has exploded. In part
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(5) Liu, J.; Yu, M.; Zhou, C.; Yang, S.; Ning, X.; Zheng, J.; J. Am. Chem. Soc., this is due to advances in MRI instrumentation, F/ H coil designs, and ultra-
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2013,. 135,4978 (6) Liu, J.; Yu, M.; Ning, X.; Zhou, C.; Yang, S.Y.; and Zheng, J.; fast pulse sequence development for both preclinical and clinical scanners.
Angew. Chem. Int. Ed., These achievements coupled with the interest in molecular imaging of
2013, 12572 anatomy and physiology combined with a cadre of innovative agents, has
(7) Yu M.X, Liu J. B., Ning X. H. and Zheng J. Angew Chem Int. Ed. , 2015, brought the concept of F to the brink of clinical use. Indeed, F/ H mole-
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DOI: 10.1002/anie.201507868 cuIar imaging may address the severe lack of clinical noninvasive imaging
(8) Liu, J.; Yu, M.; Zhou, C. and Zheng, J, Mater. Today, 2013, 477 capability for noncancer lung disease, such as asthma, emphysema, intersti-
(9) Yu M.X. and Zheng J. ACS Nano, 2015, 9, 6655 tial lung diseases, pulmonary hypertension and more.
10:40am Frozen Naphthalocyanine Micelles for Multimodal In- 12:00pm A Multi-Functional Nanoplatform For The Enhance-
testinal Imaging ment And Prediction Of Therapeutic Response To External Beam
Radiation Therapy
Technical Presentation. NEMB2016-5951
Technical Presentation. NEMB2016-5971
Yumiao Zhang, University at buffalo, buffalo, NY, United States,
Mansik Jeon, Pohang Univ of Science and Technology, Gyeo- Ajlan Al Zaki, Casey McQuade, Gary Kao, Jay Dorsey, Andrew
ngsangbuk-do, Korea (Republic), Laurie Rich, s, Roswell Park Tsourkas, University of Pennsylvania, Philadelphia, PA, United
Cancer Institute, buffalo, NY, United States, Hao Hong, University States
of Michigan, Ann Arbo, MI, United States, Jumin Geng, Paschalis
Alexandridis, University at Buffalo, Buffalo, NY, United States, Jan Gold nanoparticles have garnered interest as both radiosensitzers and
Huizinga, McMaster University, Hamilton, ON, Canada, Mukund computed tomography (CT) contrast agents. However, the extremely high
16 Seshadri, Roswell Park Cancer Institute, buffalo, NY, United States, concentrations of gold required to generate CT contrast is far beyond that
Weibo Cai, University of Wisconsin-Madison, Madison, WI, United needed for meaningful radiosensitization, which limits their use as combined
States, Chulhong Kim, Pohang University of Science and Technolo- therapeutic-diagnostic - theranostic - agents. To establish a theranostic