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Plenary Sessions

PLENARY TITLE: NANO ASPECTS IN THE PHYSICS OF CANCER: quantify delivery, the use of magnetic resonance imaging (MRI) for
FROM NUCLEAR REMODELING TO SELF-RECOGNITION FOR anatomic and functional imaging and to assess local temperature and the
GENE/DRUG DELIVERY use of ultrasound to enhance delivery. Using this combination of tech-
Date/Time: Monday, February 22, 02:30 -03:15 PM niques, we have developed activatable particles for the delivery of
Location: Grand Ballroom chemotherapeutics in cancer and targeted nanovehicles for the delivery
Presenter: Dennis Discher, University of Pennsylvania of miRNA in cardiovascular disease. Our cancer focus has involved
identifying nanodelivery strategies that are curative for local disease and
Session Description: Tissue cells, implants, and strategies that synergize with immunotherapy for the treatment of systemic
particles of any type interact with the innate immune disease. We have developed methods to load activatable particles with a
system, especially phagocytes that try to ‘eat’ metal-drug complex and to release this complex by increasing the local
everything. However, ‘Self’ cells are spared due to a temperature using ultrasound. Full release of the chemotherapeutic
polypeptide found on all cells that marks cells (as well occurs only in the region of elevated temperature and in the presence of a
as engineered viruses and particles) as ‘Self’, limiting their phagocytic reduced pH. We find that such a strategy enhances efficacy while
clearance in vitro and in vivo. The phagocyte’s cytoskeleton drives the reducing systemic toxicity. We will describe both the nanotherapeutic
decision downstream of adhesion. If an injected cell is recognized as ‘Self’ strategies and the imaging systems that facilitate this approach. In
and if it has stem-like properties, then further interactions with the addition, we have recently explored the use of targeted, coated cationic
surrounding tissue can influence its differentiation. Matrix elasticity is one particles to facilitate the delivery of biologic therapeutics to endothelial
physical feature that directs stem cell fate and reflects the fact that tissues cells and will demonstrate the imaging approaches required for the
can be very soft like fat and brain, or increasingly stiff like striated muscle optimization of such a design and the resulting efficacy in cardiovascular
and rigid like bone. Stem and progenitor cells use myosin-II to feel and disease.
respond to such elasticity differences, with physical signals propagating all
the way into the nucleus, which feeds back on gene expression. What Bio: Katherine Whittaker Ferrara is a Distinguished Professor of Biomedical
unifies these mechanisms of immune or matrix recognition is a conver- Engineering at UC Davis and the Director of theCenter for Content Rich
gence of decision-making pathways on cytoskeletal force generation. Evaluation of Therapeutic Efficacy (cCRETE). She is a member of the
National Academy of Engineering and a fellow of the IEEE, American
Bio: Dennis E. Discher is the Robert D. Bent Chair Professor and Director of Association for the Advancement of Science, the Biomedical Engineering
the NCI-funded Physical Sciences Oncology Center at the University of Society, the Acoustical Society of America and the American Institute of
Pennsylvania. He received a Ph.D. jointly from the University of California, Medical and Biological Engineering. She currently chairs the Clinical
Berkeley and San Francisco in 1993 for biophysical studies of cell Molecular Imaging Probes (CMIP) NIH study section. Dr. Ferrara received
membranes, and was a U.S. National Science Foundation International her Ph.D. in 1989 from the University of California, Davis. Prior to her PhD,
Fellow in computational biophysics at the University of British Columbia Dr. Ferrara was a project engineer for General Electric Medical Systems,
until 1996. He has coauthored more than 200 publications with >30,000 involved in the development of early magnetic resonance imaging and
citations that range in topic from matrix effects on stem cells and physical ultrasound systems. Following an appointment as an Associate Professor
properties of the cell nucleus to mechanisms of ‘self’ recognition by in the Department of Biomedical Engineering at the University of Virginia,
macrophages and self-assembling polymers applied to disease, with Charlottesville, Dr. Ferrara served as the founding chair of the Department
papers appearing in Science, Cell, and various Nature journals. ISI lists of Biomedical Engineering at UC Davis. Her laboratory is known for early
‘Matrix elasticity directs stem cell lineage specification’ (Cell 2006) as the work in aspects of ultrasonics and has more recently expanded their focus
3rd most cited experimental research paper in the field of Molecular to broadly investigate molecular imaging and drug delivery. Dr. Ferrara’s
Biology & Genetics since 2004. Additional honors and service include: laboratory has received numerous awards including the Achievement
election to the U.S. National Academy of Engineering, a Presidential Early Award from the IEEE Ultrasonics, Ferroelectrics and Frequency Control
Career Award for Scientists and Engineers from the U.S. National Science Society, which is the top honor of this society.
Foundation, the Friedrich Wilhelm Bessel Award from the Humboldt
Foundation of Germany, a LabEx Visiting Fellow at the Institut Jacques
Monod – Paris, and membership on the Editorial Board for Science.
PLENARY TITLE: DIRECT CELL REPROGRAMMING VIA GENOME
EDITING
Date/Time: Tuesday, February 23, 02:30-03:15 PM
PLENARY TITLE: IMAGE-GUIDED NANOTHERAPY IN THE Location: Grand Ballroom
TREATMENT OF CANCER AND CARDIOVASCULAR DISEASE Presenter: Kam W. Leong, Columbia University
Date/Time: Tuesday, February 23, 08:30-09:15 AM
Location: Grand Ballroom Bio: Kam W. Leong is the Samuel Y. Sheng Professor of
Presenter: Katherine Whittaker Ferrara, University of Biomedical Engineering at Columbia University. His
California, Davis lab works on nanoparticle-mediated nonviral gene
delivery and immunotherapy—from design and
Session Description: In vivo imaging can greatly synthesis of new carriers to applications for hemophil-
enhance the optimization of nanodelivery methods. In ia and infectious diseases. The lab also works on the application of 13
our laboratory, we combine the use of positron nanostructured biomaterials for regenerative medicine, particularly on
emission tomography (PET) and optical imaging to understanding cell-topography interactions and on the application of