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社会焦点 CLINICAL
临床研究 SOCIAL FOCUSRESEARCH 振东学术·ZHENDONG SCIENCE

老年高血压患者血清
老年高血压患者血清UA CK Cys-C APNUA CK Cys-C APN水平水平
与颈动脉粥样硬化之间的关系
与颈动脉粥样硬化之间的关系
马旃，雷海玲，孙华毅
（北京积水潭医院心内科，北京 100035）
【摘要】目的：分析老年高血压患者血清尿酸（UA）、肌酸激酶（CK）、胱抑素C（Cys-C）、脂联素（APN）水平与
颈动脉粥样硬化之间的关系。方法：选择我院2018年4月至2019年4月收治的老年高血压患者110例为研
究对象，根据患者颈动脉内膜中层厚度（IMT）分为IMT正常组（36例）、IMT增厚组（31例）、斑块形成组（43
例）三组，检测患者血清UA、CK、Cys-C、APN水平，分析IMT与上述指标的相关性，并对影响老年高血压患

者颈动脉粥样硬化的因素进行Logistic回归模型分析。结果：随着IMT增厚程度增加，血清UA、CK、Cys-C
水平逐渐升高，其水平IMT正常组<IMT增厚组<斑块形成组（P<0.05），APN水平逐渐降低，其水平IMT正
常组>IMT增厚组>斑块形成组（P<0.05）；Pearson相关性分析显示，IMT与UA、CK、Cys-C呈正相关（P<0.05），与
APN呈负相关（P<0.05）；二元Logistic回归模型分析，结果显示，血清UA、CK、Cys-C、APN是影响老年高血
压患者颈动脉粥样硬化的独立危险因素（P<0.05）。结论：老年高血压患者颈动脉粥样硬化程度与血清UA、

CK、Cys-C水平升高以及APN水平降低有关。
【关键词】颈动脉粥样硬化；尿酸；肌酸激酶；胱抑素C；脂联素；老年高血压
【中图分类号】R543.4；R544.1；R341.35 【文献标识码】A 【文章编号】1006-6233(2020)05-0755-04

Relationship Between Levels of Serum UA,CK,Cys-C and APN and Carotid AtherosclerosisBetween Levels of Serum UA,CK,Cys-C and APN and Carotid Atherosclerosis
Relationship
in Elderly Patients with HypertensionElderly Patients with Hypertension
in
Ma Zhan, Lei Hailing, Sun Huayi

(Beijing Jishuitan Hospital, Peking University, Beijing 100035, China)
[Abstract]
[Abstract] ObjectiveObjective: To analyze the relationship between levels of serum uric acid (UA), creatine kinase (CK), cystatin
C (Cys-C), adiponectin (APN) and carotid atherosclerosis in elderly patients with hy pertension. MethodsMethods:A total of 110

elderly patients with hypertension admitted to our hospital from April 2018 to April 2019 were selected for the study.
The patients were divided into normal IMT group (36 cases), IMT thickening group (31 cases) and plaque formation
group(43 cases)according to the carotid intimamedia thickness (IMT).The levels of serum UA,CK,Cys-C and APN
were detected,and the correlation between IMT and above indicators was analyzed,and the factors affecting carotid
atherosclerosis in elderly hypertensive patients were analyzed by Logistic regression model. ResultsResults:With the in-

crease of IMT thickening,the levels of serum UA,CK and Cys-C were increased gradually,and the levels showed
normal IMT group<IMT thickening group<plaque formation group (P<0.05), and the APN level was gradually de-
creased,and the level showed normal IMT group>IMT thickening group>plaque formation group (P<0.05). Pearson
correlation analysis showed that IMT was positively correlated with UA,CK and Cys-C (P<0.05), and was negatively

correlated with APN (P<0.05). Binary Logistic regression model analysis showed that serum UA,CK,Cys-C and
APN were independent risk factors for carotid atherosclerosis in elderly hypertensive patients (P<0.05). ConclusionConclusion:

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