Page 337 - 00. Complete Version - Progress Report IPEN 2014-2016

Materials and Nanotechnology | Progress Report 337

Figure 63. SEM of the Europium and terbium supermolecules.

Development of a low cost diagnostic kit main methodology used for the detection of
that use luminescent Nanobiomarkers HbS was fluoroimunoassay, which is already
for use in sickle cell anemia used in investigation of enzymes, antibodies,
cells, hormones, and so on. The studied meth-
Luminescent materials, such as the rare earth’s ods were applied for the diagnosis of this dis-
complex, can be used as markers in cytology ease, which has genetic origin, very typical
and immunology, being also used as lumi- of the hemoglobin-pathology group and con-
nescent biomarkers, once the development of sidered to be a public health problem in Brazil
these nanomaterials create new possibilities (ANVISA). When is early detected, Sickle Cell
in many fields, particularly in diagnostic med- Disease (SCD) has a significant decrease in mor-
icine. Besides, it establishes one kind of fluo- bidity and mortality. Comparing the obtained
rescent probes, for which there are no equiva- results to the already known methodologies,
lent organic molecules. Due to its potential in it was possible to conclude that they are via-
market’s application, the objective of this work ble methods to detect HbS. Besides, when to-
was to develop luminescent materials, allow- tally developed, these methods will contrib-
ing the use of these supermolecules of lantha- ute to the production of Sickle Cell Anemia’s
nides as markers for the detection of Sickle Cell diagnostic, and they will have impact in São
Disease (HbS). Six luminescent markers were Paulo state’s public measures, as well as in
developed based on rare earth compounds. The Brazil’s ones. An prototype kit is in the vali-