Page 351 - Pharmacology Mnemonics and Short Notes

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 Pyrimethamine + sulfadoxine  Fensidar (used in Chloroquine
resistant p-falciparum

 Proguanil + atvaquone  Malarone (chemoprophylaxis of
chloroquine resistant malaria)

Adverse effects

Anti-folate HINGE

H  hemolysis

I  Drug interactions (competition with plasma proteins)

N  Nephrotic damage

G  GIT distress

Other Antimalarial Drugs

Doxycycline  Tetracycline  chemoprophylactic

Amodiaquine  used against chloroquine resistant p-falciparum (Low
cost drug)

Atovaquone  Quine derivative (Disrupt mitochondrial electron

transport)  Chemoprophylaxis and treatment of p-falciparum malaria

Halofantrine  Halo > whole  active against erythrocytic stages of all
4 forms of malaria

Artemisinins  only drug reliably effective against Quinine resistant
strains

Travellers Malaria

1) Chloroquine is used as prophylaxis

Contents 2) Chloroquine resistant  Mefloquine

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman