Page 349 - Pharmacology Mnemonics and Short Notes

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Complexes with Double stranded DNA to prevent strand separation 
Block DNA Replication and transcription of RNA

Clinical use

 P falciparum infections resistant to chloroquine

 Used with doxycycline and clindamycin (to shorten duration of
toxicity and limit toxicity

 Should not be used for prophylaxis (to delay resistance emergence)

Toxicity

BC got his TV

 Black water fever  Hematotoxic effects

 Cinchonism

o Got  GIT disturbances

o His  headache

o T  tinnitus (ringing in ears)

o V  Vision blurred

Mefloquine

 First line of drug taken for prophylaxis in all geographical areas with
chloroquinine resistance

 Alternative to quinine in acute attacks

 In uncomplicated infection resulting from p falciparum

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman