Page 344 - Pharmacology Mnemonics and Short Notes

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Uses

 Supress replication of HBV

Side-effect  nephrotoxic

Lamivudine

Nucleoside inhibition of HIV reverse transcriptase

Uses

 Supress replication of HBV

 Used in HAART (highly active acute antiretroviral therapy)

IFN alpha

Interferon alpha

Mechanism

 Activates JACK & STATS  formation of antiretroviral proteins is

activated

 Activates host cell ribonuclease  Degrade viral mRNA

Pharmacokinetics elimination  proteolytic hydrolysis in kidney

Uses

 Hep B  alone or in combination with others

 Hep C  Combination with ribavirin to reduce progression

 CMV infection

 Herpes zoster infection

Entecavir

Guanicine nucleotide  inhibit DNA polymerase

Contents Use  effective against HBV

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman