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Entry inhibitors  en  Enfuvirtide

 Attach to Gp41 unit of viral envelop  prevent conformational

changes required for cellular fusion

Other anti-viral Drugs

Fomivirsen

 FOM  Bind to mRNA of CMV  Block initial step of protein

synthesis

 Injected IV for treatment of CMV retinitis

Etravirin

 Newest drug  effective against HIV resistant strains

Nevirapine

 Metabolized by cyp3A4

 Nevirapin  N  Neonates  Prevent vertical transmission of HIV
when given in single dose to mother at the onset of the labour

Anti-Influenza Drugs

1) Amantadine and Rimetadine
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Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman