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 GIT distress (ulcers), CNS effects

 Nephrotoxic

 Electrolyte imbalance

Protease inhibitors

Mechanism

Aspartate protease  enzyme that convert precursor polypeptides into
final structural Proteins of Mature Virion

 They are used in combination with other Drugs

Drunavir

 Daro na  used where resistance to other drugs is developed

Fosamprenavir

 Hydrolysis to produce Amprenavir

 Not used in children and pregnant women

Indinavir

 Good oral bioavailability (except in the presence of food)

 Side effects  Indina  India  baharat

o India  insulin resistance

o Baharat Increase Bilirubin (jaundice)

Effects Produced by Protease inhibitors

 Disorders of carbohydrate and lipid metabolism

 Insulin resistance

 Sex hormone abnormality  gynecomastia

Contents Entry inhibitors

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman