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 It is competitive substrate for DNA Polymerase

 Also produces changes in DNA polymerase (alteration of structure)

Pharmacokinetics  short half live  multiple doses per day

Clinical Uses

 Mucocutaneous herpes

 AIDS

 Immunocompromised persons

Adverse effects

Cycle have two new designs

Cycle  Acyclovir side effects

Have  Hypertension

Two  Tremors

New  Nephrotoxicity

Designs  Delirium

Ganciclovir

Guanine derivative

Mechanism

Phosphorylated by thymidine kinase to produce nucleotide that inhibit
DNA polymerase

 Inhibit DNA Polymerase  Inhibit nucleic acid synthesis

Uses

 In herpes as from above

 In DNA G pairs with C  G= C so
Contents o C  Cytomegalovirus infection s

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman