Page 339 - Pharmacology Mnemonics and Short Notes

331

 Act as chain terminators  block attachment of next nucleotide

Members

Abay ka veer Lamba zidi hay

 Abacavir

 Lamivudine  hep B and HAART (highly active antiretroviral

therapy)

 Zidovudine

Also called azidothymidine (AZT)

 Uses

o First Drug to be discovered for treatment of AIDS

o Post exposure prophylaxis

o Pregnancy prophylaxis

 Side effects

o Zid  zero RBCs  Causes anemia (megaloblastic anemia) 
because this causes bone marrow suppression

o Other effects  GIT distress, CNS effects (headache) and
hepatotoxic

Non-Nucleoside reverse transcriptase inhibitors

Mechanism

 Site of action different from NRTIs

 They doesnot require phosphorylation for activation

 Non-nucleoside  do not compete for Nucleoside phosphate

 Resistance  develop rapidly if used alone (monotherapy)

Contents Adverse effects

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman