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Adverse effect  fatigue, nausea and headache

Tenofovir

NRTIs (nucleoside analogue reverse transcriptase inhibitor)

Use  effective against HBV

Ribavirin

Mechanism

Make the native nucleoside drug resemble adenosine or guanosine,

depending on its rotation  incorporated into RNA, as a base analogue
of either adenine or guanineinducing mutations in RNA-dependent
replication in RNA (Hypermutation) lethal to RNA viruses.

 Ribavirin  R  incorporated into RNA  lethal mutations

Uses

 Adjuncts in chronic hepatitis C infection with IFN alpha

 Monotherapy not effective

Toxicity

Ribavirin  R  effect RBCs  Dose dependant haemolytic anemia

 Teratogenic  so contraindicated in pregnancy

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman