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Chloroquine

Mechanism

Chloroquine  accumulate in food vacuole  Prevent polymerization of
Heme into hemozin  accumulation of Heme  Cytotoxic to Parasite

Resistance

 Decrease intracellular accumulation by increased activity of
membrane pumps

 Intravascular accumulation of Chloroquine via transporter encoded
by pfcrt (Plasmodium falciparum Chloroquine resistance
transporter)

Uses

 Non falciparum and sensitive falciparum malaria Treatment and
prophylaxis

 In autoimmune diseases (rheumatic arthritis)

 Radiosenstizing in anticancer therapy

Adverse effects

G Rana sahib

G  GIT irritation

R  Renal damage

A  Auditory damage

N  Neuropathies

A  attacks of porphyria

Sahib  Skin rash and skin lesions

Quinine
Contents Mechanism

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman