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43. Anti-Microbial Drugs

Metronidazole

Imidazole Derivative

 Active against Protozoa and Bacteria

Mechanism

Reductive bioactivation of nitro Group by Ferridoxin  and form reactive
cytotoxic products

Reactive Nucleic
Nitro Bioactivated
acid
group by cytotoxic synthesis
products
of drug Ferredoxin
formed dysrupted

Clinical Uses

ABCDEFGH

A  Amebiasis and Anaerobic

streptococci infections

B  Bacteroids infection

C  Clostridium perferenges infection

D  D-medinensis infection

E  pseudomembranous enterocolitis and Entameba infection

Contents F  Fusobacterium infection

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman