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Toxicity

Psycho cat have some Gastric disease

Psycho  psychiatric diseases

Cat  CVS disorders

Have  headache

Some  skin rash

Gastric  GIT disturbances

Disease  dizziness

Primaquine

Form Quinoline quinone metabolites  electron transferring redox
compounds  cellular oxidants  killing of gametes of plasmodium

 Tissue schizonticide  Gametocide

Clinical use

 Eradicate Liver stages of p vivax and P ovale

 Used in conjugation with blood schizonticides (Not active alone)

 14day treatment of primaquine is standerd after treatment with
chloroquine

 Alternative for primary prevention

Anti-folate drugs

Pyrimethamine, Proguanil, sulfadoxine and dapsone are used

Mechanism

Act as antimetabolites of PABA and inhibit synthesis of folic acid

Clinical uses
Contents  Blood schizonticide against p falciparum

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman