Page 85 - Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine

Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the.. .

Nakamura Y, Miyaki S, Ishitobi H, Matsuyama S, mediated transfer of miR-133b from multipotent mes-
Nakasa T, Kamei N, Akimoto T, Higashi Y, Ochi M enchymal stromal cells to neural cells contributes to
(2015) Mesenchymal-stem-cell-derived exosomes neurite outgrowth. Stem Cells 30:1556–1564
accelerate skeletal muscle regeneration. FEBS Lett Xin H, Li Y, Cui Y, Yang JJ, Zhang ZG, Chopp M (2013)
589:1257–1265 Systemic administration of exosomes released from
Rani S, Ryan AE, Griffin MD, Ritter T (2015) Mesenchy- mesenchymal stromal cells promote functional recov-
mal stem cell-derived extracellular vesicles: toward ery and neurovascular plasticity after stroke in rats. J
cell-free therapeutic applications. Mol Ther Cereb Blood Flow Metab 33:1711–1715
23:812–823 Yamada J, Dana MR, Sotozono C, Kinoshita S (2003)
Schey KL, Luther JM, Rose KL (2015) Proteomics char- Local suppression of IL-1 by receptor antagonist in
acterization of exosome cargo. Methods 87:75–82 the rat model of corneal alkali injury. Exp Eye Res
Shigemoto-Kuroda T, Oh JY, Kim DK, Jeong HJ, Park 76:161–167
SY, Lee HJ, Park JW, Kim TW, An SY, Prockop DJ, Yeo RW, Lai RC, Zhang B, Tan SS, Yin Y, Teh BJ, Lim
Lee RH (2017) MSC-derived extracellular vesicles SK (2013) Mesenchymal stem cell: an efficient mass
attenuate immune responses in two autoimmune producer of exosomes for drug delivery. Adv Drug
murine models: type 1 diabetes and Uveoretinitis. Deliv Rev 65:336–341
Stem Cell Rep 8:1214–1225 Yi T, Song SU (2012) Immunomodulatory properties of
Théry C, Ostrowski M, Segura E (2009) Membrane mesenchymal stem cells and their therapeutic
vesicles as conveyors of immune responses. Nat Rev applications. Arch Pharm Res 35:213–221
Immunol 9:581–593 Yoles E, Schwartz M (1998) Degeneration of spared axons
van Koppen A, Joles JA, van Balkom BW, Lim SK, de following partial white matter lesion: implications for
Kleijn D, Giles RH, Verhaar MC (2012) Human optic nerve neuropathies. Exp Neurol 153:1–7
embryonic mesenchymal stem cell-derived Yu B, Zhang X, Li X (2014) Exosomes derived from
conditioned medium rescues kidney function in rats mesenchymal stem cells. Int J Mol Sci 15:4142–4157
with established chronic kidney disease. PLoS One 7: Yu B, Shao H, Su C, Jiang Y, Chen X, Bai L, Zhang Y,
e38746 Li Q, Zhang X, Li X (2016) Exosomes derived from
Villarroya-Beltri C, Baixauli F, Gutiérrez-Vázquez C, MSCs ameliorate retinal laser injury partially by inhi-
Sánchez-Madrid F, Mittelbrunn M (2014) Sorting it bition of MCP-1. Sci Rep 6:34562
out: regulation of exosome loading. Semin Cancer Zaharie F, Muresan MS, Petrushev B, Berce C, Gafencu
Biol 28:3–13 GA, Selicean S, Jurj A, Cojocneanu-Petric R, Lisencu
Vlassov AV, Magdaleno S, Setterquist R, Conrad R CI, Pop LA, Pileczki V, Eniu D, Muresan MA,
(2012) Exosomes: current knowledge of their compo- Zaharie R, Berindan-Neagoe I, Tomuleasa C, Irimie
sition, biological functions, and diagnostic and thera- A (2015) Exosome-carried microRNA-375 inhibits
peutic potentials. Biochim Biophys Acta cell progression and dissemination via Bcl-2 blocking
1820:940–948 in colon cancer. J Gastrointestin Liver Dis 24:435–443
Volarevic V, Gazdic M, Simovic Markovic B, Jovicic N, Zhang B, Yin Y, Lai RC, Tan SS, Choo AB, Lim SK
Djonov V, Arsenijevic N (2017) Mesenchymal stem (2014) Mesenchymal stem cells secrete immunologi-
cell-derived factors: Immuno-modulatory effects and cally active exosomes. Stem Cells Dev 23:1233–1244
therapeutic potential. Biofactors 43:633–644 Zhu W, Huang L, Li Y, Zhang X, Gu J, Yan Y, Xu X,
Volarevic V, Markovic BS, Gazdic M, Volarevic A, Wang M, Qian H, Xu W (2012) Exosomes derived
Jovicic N, Arsenijevic N, Armstrong L, Djonov V, from human bone marrow mesenchymal stem cells
Lako M, Stojkovic M (2018) Ethical and safety issues promote tumor growth in vivo. Cancer Lett 315:28–37
of stem cell-based therapy. Int J Med Sci 15:36–45 Zöller M (2009) Tetraspanins: push and pull in
Xin H, Li Y, Buller B, Katakowski M, Zhang Y, Wang X, suppressing and promoting metastasis. Nat Rev Cancer
Shang X, Zhang ZG, Chopp M (2012) Exosome- 9:40–55