Page 58 - Cardiac Electrophysiology | A Modeling and Imaging Approach

P. 58
Figure 2.37. Effects of
HERG mutations on
whole-cell AP. A. AP
(1000th paced beat
at CL=750msec). B. I
Kr
during the AP. C-G.
channel occupancy of
the indicated kinetic
states over the course
of the AP. Left
column: wild-type
(WT); middle column:
T474I mutation; right
column: R56Q
mutation. Arrows
indicate presence of
a late peak in open-
state residency in WT
and T474I and its
absence in R56Q.
From Clancy and Rudy
[71], with permission
from Oxford University
Press.

A B

Figure 2.38. Simulation of HERG N629D mutation. AP and I during the AP are shown for
Kr
(A) epicardial cell and (B) M cell. Arrows indicate the inward phase of I . Adapted from Clancy
Kr
and Rudy [138], with permission from Oxford University Press.